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Titolo:
Sustained effects of gene-activated matrices after CNS injury
Autore:
Berry, M; Gonzalez, AM; Clarke, W; Greenlees, L; Barrett, L; Tsang, W; Seymour, L; Bonadio, J; Logan, A; Baird, A;
Indirizzi:
Select Genet Inc, San Diego, CA 92121 USA Select Genet Inc San Diego CA USA 92121 enet Inc, San Diego, CA 92121 USA GKT, Ctr Neurosci Neural Damage & Repair, London SE1 1UL, England GKT London England SE1 1UL ural Damage & Repair, London SE1 1UL, England Univ Birmingham, Dept Med, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England Univ Birmingham, Dept Canc Studies LS, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 4, volume: 17, anno: 2001,
pagine: 706 - 716
SICI:
1044-7431(200104)17:4<706:SEOGMA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; FIBROBLAST GROWTH-FACTOR; SPINAL-CORD INJURY; OPTIC-NERVE; IN-VIVO; NEUROTROPHIC FACTOR; ADULT-RATS; APOPTOSIS; REGENERATION; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Baird, A Select Genet Inc, 11035 Roselle St, San Diego, CA 92121 USA Select Genet Inc 11035 Roselle St San Diego CA USA 92121 2121 USA
Citazione:
M. Berry et al., "Sustained effects of gene-activated matrices after CNS injury", MOL CELL NE, 17(4), 2001, pp. 706-716

Abstract

We show that when gene-activated matrices (GAM) are placed between the proximal and distal stumps of severed rat optic nerves, DNA is retained withinthe GAM, promoting sustained transgene expression in the optic nerve, in the GAM itself, and, more importantly, in axotomized retinal ganglion cells (ROC), Plasmids that encode basic fibroblast growth factor (FGF2), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT3) promote sustained survival of RGC for over 3 months after the initial injury. These findings suggest that immobilized DNA implanted into a CNS lesion will be delivered by axon terminal uptake and retrograde transport to axotomized neurons. GAM may therefore be a useful agent for promoting sustained neuron survival and axon regeneration. Whether further optimization of the matrices, plasmids, promoters, and genes present in the GAM will promote even more survivalor, alternatively, axon regeneration remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:03:05