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Titolo:
Overexpression of MATH1 disrupts the coordination of neural differentiation in cerebellum development
Autore:
Helms, AW; Gowan, K; Abney, A; Savage, T; Johnson, JE;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 , Ctr Basic Neurosci, Dallas, TX 75390 USA
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 4, volume: 17, anno: 2001,
pagine: 671 - 682
SICI:
1044-7431(200104)17:4<671:OOMDTC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING NERVOUS-SYSTEM; ACHAETE-SCUTE HOMOLOG-1; LOOP-HELIX PROTEIN; NEURONAL DIFFERENTIATION; GRANULE NEURONS; MOLECULAR CHARACTERIZATION; RESTRICTED EXPRESSION; NEGATIVE REGULATOR; NEUROGENIC GENES; XENOPUS EMBRYOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, JE Univ Texas, SW Med Ctr, Ctr Basic Neurosci, 5323 Harry Hines Blvd, Dallas,TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
A.W. Helms et al., "Overexpression of MATH1 disrupts the coordination of neural differentiation in cerebellum development", MOL CELL NE, 17(4), 2001, pp. 671-682

Abstract

An essential role for the bHLH transcription factor MATH1 in the formationof cerebellar granule cells was previously demonstrated in a Math1 null mouse. The function of regulated levels of MATH1 in granule cell development is investigated here using a gain-of-function paradigm. Overexpression of Math1 in its normal domain in transgenic mice leads to early postnatal lethality and perturbs cerebellar development. The cerebellum of the (B)MATH1 transgenic neonate is smaller with less foliation, particularly in the central vermal regions, when compared to wild-type cerebella. A detailed analysisof multiple molecular markers in brains overexpressing Math1 has revealed defects in the differentiation of cerebellar granule cells. NeuroD and doublecortin, markers normally distinguishing the discrete layered organizationof granule cell maturation in the inner EGL, are aberrantly expressed in the outer EGL where MATH1-positive, proliferating cells reside. In contrast,TAG-1, a later marker of developing granule cells that labels parallel fibers, is severely diminished. The elevated MATH1 levels appear to drive expression of a subset of early differentiation markers but are insufficient for development of a mature TAG-1-expressing granule cell. Thus, balanced levels of MATH1 are essential for the correct coordination of differentiation events in granule cell development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:52:52