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Titolo:
GABA(B) receptors couple directly to the transcription factor ATF4
Autore:
Vernon, E; Meyer, G; Pickard, L; Dev, K; Molnar, E; Collingridge, GL; Henley, JM;
Indirizzi:
Univ Bristol, Sch Med Sci, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 4, volume: 17, anno: 2001,
pagine: 637 - 645
SICI:
1044-7431(200104)17:4<637:GRCDTT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; NEGATIVELY REGULATE TRANSCRIPTION; CAMP RESPONSE ELEMENT; HIPPOCAMPAL-NEURONS; RAT-BRAIN; BINDING; HETERODIMERS; MECHANISMS; STORAGE; CREB-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Vernon, E Univ Bristol, Sch Med Sci, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD S8 1TD, Avon, England
Citazione:
E. Vernon et al., "GABA(B) receptors couple directly to the transcription factor ATF4", MOL CELL NE, 17(4), 2001, pp. 637-645

Abstract

The inhibitory neurotransmitter gamma -aminobutyric acid (GABA), acts at ionotropic (GABA(A) and GABA(C)) and metabotropic (GABA(B)) receptors. Functional GABA(B) receptors are heterodimers of GABA(B(1)) and GABA(B(2)) subunits. Here we show a robust, direct, and specific interaction between the coiled-coil domain present in the C-terminus of the GABA(B(1)) subunit and the transcription factor ATF4 (also known as CREB2). ATF4 and GABA(B(2)) binding to the GABA(B(1)) subunit were mutually exclusive. In rat hippocampal neurons native GABA(B(1)) showed surprisingly little similarity to GABA(B(2)) in its subcellular distribution, GABA(B(1)) and ATF4 however, were highlycolocalized throughout the cell and displayed a punctate distribution within the dendrites. Activation of GABA(B) receptors in hippocampal neurons caused a dramatic translocation of ATF4 out of the nucleus into the cytoplasm, These data suggest a novel neuronal signaling pathway that could regulatethe functional expression of GABA(B) receptors and/or modulate gene transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:36:15