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Titolo:
Cytoskeletal reorganization during the formation of oligodendrocyte processes and branches
Autore:
Song, J; Goetz, BD; Baas, PW; Duncan, ID;
Indirizzi:
Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Med Sci, Madison, WI 53706 USA Med Coll Penn & Hahnemann Univ, Dept Neurobiol & Anat, Philadelphia, PA 19129 USA Med Coll Penn & Hahnemann Univ Philadelphia PA USA 19129 ia, PA 19129 USA
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 4, volume: 17, anno: 2001,
pagine: 624 - 636
SICI:
1044-7431(200104)17:4<624:CRDTFO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED ANIMAL-CELLS; MYOSIN HEAVY-CHAINS; CYTOPLASMIC DYNEIN; CONTRACTILE RING; AMEBOID MOVEMENT; ACTIN-FILAMENTS; PLASMA-MEMBRANE; GROWTH CONES; LOCALIZATION; TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Song, J Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 ed Sci, Madison, WI 53706 USA
Citazione:
J. Song et al., "Cytoskeletal reorganization during the formation of oligodendrocyte processes and branches", MOL CELL NE, 17(4), 2001, pp. 624-636

Abstract

During oligodendrocyte development, signals relevant to process formation must be transduced into appropriate changes in cytoskeletal organization. We have explored how microtubules and microfilaments interact during the outgrowth and branching of oligodendrocyte processes in culture. We observed that microfilaments are enriched in the peripheral region beneath the plasmamembrane and constitute the major cytoskeletal element at the leading edgeof the process, which is also enriched in the B-isoform of the non-muscle myosin II heavy chain. Microtubules form a dense bundle within the process and splay before extending into the leading edge and branches, following tracks laid by microfilaments. Pharmacologic disruption of microfilaments andmicrotubules compromised normal process outgrowth and branching. However, microtubules rapidly reinvaded most processes after removal of both antimicrotubule and antimicrofilament drugs, but the reinvasion was severely compromised if the antimicrofilament drug was retained. These results are consistent with the hypothesis that microfilaments guide the local reorganizationof microtubules for the elongation of oligodendrocyte processes and the formation of new branches.

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Documento generato il 07/04/20 alle ore 03:26:09