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Titolo:
The winged-helix protein brain factor 1 interacts with Groucho and Hes proteins to repress transcription
Autore:
Yao, J; Lai, E; Stifani, S;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, Montreal, PQ H3A2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 vival, Montreal, PQ H3A2B4, Canada Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 1962 - 1972
SICI:
0270-7306(200103)21:6<1962:TWPBF1>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSDUCIN-LIKE-ENHANCER; MAMMALIAN NEURONAL DIFFERENTIATION; GROUCHO/TRANSDUCIN-LIKE ENHANCER; ACHAETE-SCUTE HOMOLOG-1; CEREBRAL HEMISPHERES; DROSOPHILA GROUCHO; NERVOUS-SYSTEM; SPLIT PROTEINS; EXPRESSION; NEUROGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Stifani, S McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 2B4, Canada
Citazione:
J. Yao et al., "The winged-helix protein brain factor 1 interacts with Groucho and Hes proteins to repress transcription", MOL CELL B, 21(6), 2001, pp. 1962-1972

Abstract

Brain factor 1 (BF-1) is a winged-helix transcriptional repressor that plays important roles in both progenitor cell differentiation and regional patterning in the mammalian telencephalon. The aim of this study was to elucidate the molecular mechanisms underlying BF-I functions. It is shown here that BF-I interacts in vivo dth global transcriptional corepressors of the Groucho family and also associates with the histone deacetylase 1 protein. The ability of BF-1 to mediate transcriptional repression is promoted by Groucho and inhibited by the histone deacetylase inhibitor trichostatin A, suggesting that BF-1 recruits Groucho and histone deacetylase activities to repress transcription. Our studies also provide the first demonstration that Groucho mediates a specific interaction between BF-I and the basic helix-loop-helix protein Hes1 and that BF-1 potentiates transcriptional repression by Hes1 in a Groucho-dependent manner. These findings suggest that Groucho participates in the transcriptional functions of BF-I by acting as both a corepressor and an adapter between BF-1 and Heel. Taken together with the demonstration that these proteins are coexpressed in telencephalic neural progenitor cells, these results also suggest that complexes of BF-1, Groucho, and Hes factors may be involved in the regulation of progenitor cell differentiation in the telencephalon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:52:08