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Titolo:
Neuroimaging in headache
Autore:
Goadsby, PJ;
Indirizzi:
Natl Hosp Neurol & Neurosurg, Neurol Inst, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG n WC1N 3BG, England
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 3, volume: 53, anno: 2001,
pagine: 179 - 187
SICI:
1059-910X(20010501)53:3<179:NIH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; CHRONIC PAROXYSMAL HEMICRANIA; TRIGEMINAL GANGLION-CELLS; INDUCED CLUSTER HEADACHE; SUPERIOR SAGITTAL SINUS; NITRIC-OXIDE SYNTHESIS; ORBITAL PHLEBOGRAPHY; SUBSTANCE-P; SPREADING DEPRESSION;
Keywords:
migraine; cluster headache; MRI; PET; brainstem; hypothalamus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
132
Recensione:
Indirizzi per estratti:
Indirizzo: Goadsby, PJ Inst Neurol, Queen Sq, London WC1N 3BG, England Inst Neurol Queen Sq London England WC1N 3BG C1N 3BG, England
Citazione:
P.J. Goadsby, "Neuroimaging in headache", MICROSC RES, 53(3), 2001, pp. 179-187

Abstract

Neuroimaging of primary headache syndromes, such as cluster headache and migraine, has begun to provide a glimpse of the neuroanatomical and physiological basis of the conditions. Although these headache types have been widely described as vascular, there is now considerable imaging and clinical evidence to suggest that they are primarily driven from the brain. The sharedanatomical and physiological substrate for both of these clinical problemsis the neural innervation of the cranial circulation. Functional imaging with positron emission tomography (PET) has shed light on the genesis of both syndromes, documenting activation in the midbrain and pens in migraine, and in the hypothalamic grey in cluster headache. These areas are involved not simply as a response to first division nociceptive pain impulses but specifically in each syndrome, probably in some permissive or dysfunctional role. In a recent PET study in cluster headache, as well as brain activation,tracer pooled in the region of the major basal arteries. This is likely tobe due to vasodilatation of these vessels during the acute pain-attack andrepresents the first convincing activation of neural vasodilator mechanisms in humans. The author takes the view that the known physiology and pathophysiology of the systems involved dictate that these disorders should be collectively regarded as neurovascular headaches to place emphasis on the interaction between nerves and vessels, which is the underlying characteristicof these syndromes. Understanding this neurovascular relationship facilitates an understanding of the pain mechanisms, while characterising the CNS dysfunction will ultimately allow us to dissect out the basic pathogenesis of these disorders. RES. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:06:21