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Titolo:
Insulin secretory dysfunction and insulin resistance in the pathogenesis of Korean type 2 diabetes mellitus
Autore:
Kim, DJ; Lee, MS; Kim, KW; Lee, MK;
Indirizzi:
Sung Kyun Kwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Endocrinol & Metab, Seoul 135710, South Korea Sung Kyun Kwan Univ Seoul South Korea 135710 , Seoul 135710, South Korea
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 5, volume: 50, anno: 2001,
pagine: 590 - 593
SICI:
0026-0495(200105)50:5<590:ISDAIR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED GLUCOSE-TOLERANCE; HOMEOSTASIS MODEL ASSESSMENT; JAPANESE-AMERICAN MEN; YONCHON COUNTY; RISK-FACTORS; BETA-CELLS; FOLLOW-UP; NIDDM; PREVALENCE; HYPERINSULINEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, MK Sung Kyun Kwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Endocrinol & Metab, 50 Ilwon Dong, Seoul 135710, South Korea Sung Kyun Kwan Univ 50 Ilwon Dong Seoul South Korea 135710 Korea
Citazione:
D.J. Kim et al., "Insulin secretory dysfunction and insulin resistance in the pathogenesis of Korean type 2 diabetes mellitus", METABOLISM, 50(5), 2001, pp. 590-593

Abstract

Although insulin resistance has been shown to be a primary defect causing type 2 (non-insulin-dependent) diabetes mellitus in Pima Indians and Caucasians, insulin secretory defect has also been known to be an important factor in the development of type 2 diabetes. We undertook a study to investigate the initial abnormality of glucose intolerance in Koreans. A total of 370Korean subjects were classified into 5 groups according to their degree ofglucose intolerance (normal fasting glucose [NFG]/normal glucose tolerance[NGT], n = 95; impaired fasting glucose [IFG]/NGT, n = 29; NFG/impaired glucose tolerance [IGT], n = 60; IFG/IGT, n = 68; diabetes, n = 118). Insulinogenic index was used as an index of early-phase insulin secretion. Insulinresistance was assessed by the R value of the homeostasis model assessment[HOMA(R)]. Insulinogenic index significantly decreased in subjects with IFG/NGT and NFG/IGT compared with those with NFG/NGT. However, there was no significant difference in HOMA(R) between subjects with NFG/NGT and those with IFG/NGT or NFG/IGT. Insulinogenic index decreased significantly with theincrease of plasma glucose 120-minute value at the earlier stage of glucose intolerance compared with HOMA(R). These results suggest that early-phaseinsulin secretory defect may be the initial abnormality in the developmentof type 2 diabetes in Korean subjects. Copyright (C) 2001 by W.B. SaundersCompany.

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Documento generato il 27/11/20 alle ore 13:52:54