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Titolo:
Gene polymorphisms of hemostasis and coronary risk
Autore:
Hellstern, P; Bach, J; Haubelt, H; Preiss, A; Winkelmann, BR; Senges, J;
Indirizzi:
Klinikum Stadt Ludwigshafen, Inst Hamostaseol & Transfus Med, D-67063 Ludwigshafen, Germany Klinikum Stadt Ludwigshafen Ludwigshafen Germany D-67063 shafen, Germany
Titolo Testata:
MEDIZINISCHE KLINIK
fascicolo: 4, volume: 96, anno: 2001,
pagine: 217 - 227
SICI:
0723-5003(20010415)96:4<217:GPOHAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
GER
Soggetto:
ISCHEMIC-HEART-DISEASE; FACTOR-V-LEIDEN; PLASMINOGEN-ACTIVATOR INHIBITOR; FACTOR-VII GENE; PROTHROMBIN G20210A POLYMORPHISM; ARTERIAL THROMBOTIC DISEASE; ACUTE MYOCARDIAL-INFARCTION; PLATELET GLYCOPROTEIN IIIA; 2 SILENT POLYMORPHISMS; BETA-FIBRINOGEN GENE;
Keywords:
coronary heart disease; acute coronary syndromes; coronary risk; hemostasis; gene polymorphisms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Hellstern, P Klinikum Stadt Ludwigshafen, Inst Hamostaseol & Transfus Med,Bremserstr 79, D-67063 Ludwigshafen, Germany Klinikum Stadt Ludwigshafen Bremserstr 79 Ludwigshafen Germany D-67063
Citazione:
P. Hellstern et al., "Gene polymorphisms of hemostasis and coronary risk", MED KLIN, 96(4), 2001, pp. 217-227

Abstract

Hemostatic disorders are substantially involved in the pathogenesis of coronary heart disease and acute coronary syndromes, In addition to biochemical markers, gene polymorphisms of hemostasis have been intensively studied in terms of their association with coronary risk. These include polymorphisms of the genes of platelet glycoproteins. fibrinogen, prothrombin, Factors V, VIII and XIII, plasminogen activator inhibitor-1 and tissue-type plasminogen activator. An association of a certain gene polymorphism with an increased coronary risk has usually been demonstrated in retrospective case-control studies. However, numerous clinical studies have not yet been able to identify any of these polymorphisms as unequivocal risk factors of coronary heart disease or acute coronary syndromes. These inconsistencies are mainlydue to the complexity of the pathogenesis of coronary heart disease and the minor contribution of a single polymorphism to total coronary risk. This review reports on essential requirements of future studies as a prerequisite to improve our understanding of the genetic basis of coronary heartdisease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:05:26