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Titolo:
Accurate phosphorus metabolite images of the human heart by 3D acquisition-weighted CSI
Autore:
Pohmann, R; von Kienlin, M;
Indirizzi:
Univ Wurzburg, Dept Biophys, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 iophys, D-97070 Wurzburg, Germany
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 5, volume: 45, anno: 2001,
pagine: 817 - 826
SICI:
0740-3194(200105)45:5<817:APMIOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; CORONARY-ARTERY DISEASE; P-31 NMR-SPECTROSCOPY; ENERGY PHOSPHATE-METABOLISM; HYPERTROPHIC CARDIOMYOPATHY; DILATED CARDIOMYOPATHY; MR SPECTROSCOPY; RESOLUTION; REJECTION; SPECTRA;
Keywords:
chemical shift imaging; acquisition weighting; spatial resolution; cardiac P-31 spectroscopy; high-energy phosphates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: von Kienlin, M Hoffmann La Roche Pharmaceut, Bldg 68-05,Grenzachertr 124, CH-4070 Basel, Switzerland Hoffmann La Roche Pharmaceut Bldg 68-05,Grenzachertr 124 Basel Switzerland CH-4070
Citazione:
R. Pohmann e M. von Kienlin, "Accurate phosphorus metabolite images of the human heart by 3D acquisition-weighted CSI", MAGN RES M, 45(5), 2001, pp. 817-826

Abstract

Fourier imaging modalities suffer from significant signal contamination between adjacent voxels, especially when the spatial resolution is comparableto the size of the anatomical structures. This contamination can be positive or negative, depending on the spatial response function and the geometryof the object. Such a situation arises in human cardiac P-31 chemical shift imaging (CSI), Acquisition-weighted CSI reduces this contamination substantially, which is demonstrated by comparing conventional CSI to Hanning-weighted 3D P-31-CSI experiments in 13 healthy volunteers at 2 T. The nominal spatial resolution and the total number of scans were identical for both experiments. The improved spatial response function of the acquisition-weighted experiment led to a significantly (P < 0.0001) higher myocardial PCr/ATPratio (2.05 +/- 0.31, mean +/- SD, N = 33, corrected for saturation and blood contribution) compared to the conventional CSI experiment (1.60 +/- 0.46). This is explained by the absence of negative contamination from skeletal muscle, which also resulted in an increase of the observed SNR (from 5.4 /- 1.4 to 7.2 +/- 1.4 for ATP). With acquisition-weighted CSI, metabolic images with a nominal resolution of 16 mi could be obtained in a measurementtime of 30 min. After correction for the inhomogeneous B, field of the surface coil, these images show uniform ATP distribution in the entire myocardium, including the posterior (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:27:52