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Titolo:
Detection of myocardial viability based on measurement of sodium content: A Na-23-NMR study
Autore:
Horn, M; Weidensteiner, C; Scheffer, H; Meininger, M; de Groot, M; Remkes, H; Dienesch, C; Przyklenk, K; von Kienlin, M; Neubauer, S;
Indirizzi:
Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 d Klin, D-97080 Wurzburg, Germany Univ Wurzburg, Inst Phys, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 nst Phys, D-8700 Wurzburg, Germany Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA Hosp Good Samaritan Los Angeles CA USA 90017 t, Los Angeles, CA 90017 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 5, volume: 45, anno: 2001,
pagine: 756 - 764
SICI:
0740-3194(200105)45:5<756:DOMVBO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; PERFUSED RAT-HEART; CORONARY-ARTERY OCCLUSION; INTRACELLULAR SODIUM; HIBERNATING MYOCARDIUM; VENTRICULAR-FUNCTION; ENERGY-METABOLISM; INFARCT SIZE; NMR; ISCHEMIA;
Keywords:
Na-23 NMR; viability; myocardial infarction; hibernating; stunning; 3D-CSI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Horn, M Univ Wurzburg, Med Klin, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 many
Citazione:
M. Horn et al., "Detection of myocardial viability based on measurement of sodium content: A Na-23-NMR study", MAGN RES M, 45(5), 2001, pp. 756-764

Abstract

MRI of total sodium (Na) content may allow assessment of myocardial viability, but information on Na content in normal myocardium, necrotic/scar tissue, and stunned or hibernating myocardium is lacking. Thus, the aims of thestudy were to: 1) quantify the temporal changes in myocardial Na content postmyocardial infarction (Mr) in a rat model (Protocol 1); 2) compare Na innormally perfused, hibernating, and stunned canine myocardium (Protocol 2); and 3) determine whether, in buffer-perfused rat hearts, infarct scar canbe differentiated from intact myocardium by Na-23-MRI (Protocol 3), In Protocol 1, rats were subjected to LAD ligation. Infarct/scar tissue was excised at control and 1, 3, 7, 28, 56, and 128 days post-MI (N = 6-8 each), Na content was determined by Na-23-NMR spectroscopy (MRS) and ion chromatography. Na content was persistently increased at all time points post-MI averaging 306*-160*% of control values (*P < 0.0083 vs. control). In Protocol 2, Na-23-MRS of control (baseline), stunned and hibernating samples revealed no difference in Na. In Protocol 3, 23Na-MRI revealed a mean increase in signal intensity, to 142 +/- 6% of control values, in scar tissue. A thresholdof 2 standard deviations of the image intensity allowed determination of infarct size, correlating with histologically determined infarct size (r = 0.91, P < 0.0001), (C) 2001 Wiley-Liss, Inc.

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Documento generato il 29/09/20 alle ore 23:44:37