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Titolo:
HLA class II alleles in Chinese patients with hepatocellular carcinoma
Autore:
Donaldson, PT; Ho, S; Williams, R; Johnson, PJ;
Indirizzi:
Univ Newcastle, Liver Res Ctr, Sch Clin Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Univ Newcastle Newcastle Upon Tyne Tyne & Wear England NE2 4HH r, England Chinese Univ Hong Kong, Prince Wales Hosp, Sir YK Pao Canc Ctr, Dept Clin Oncol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Royal Free & Univ Coll Med Sch, Inst Hepatol, London, England Royal Free &Univ Coll Med Sch London England Hepatol, London, England
Titolo Testata:
LIVER
fascicolo: 2, volume: 21, anno: 2001,
pagine: 143 - 148
SICI:
0106-9543(200104)21:2<143:HCIAIC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-B VIRUS; CERVICAL INTRAEPITHELIAL NEOPLASIA; P53 GENE; NASOPHARYNGEAL CARCINOMA; AUTOIMMUNE HEPATITIS; SOUTHERN CHINESE; VIRAL-HEPATITIS; HIGH-RISK; C VIRUS; INFECTION;
Keywords:
hepatocellular carcinoma (HCC); human leucocyte antigens (HLA); hepatitis B virus (HBV); Hong Kong Chinese, susceptibility; genetic associations, susceptibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Donaldson, PT Univ Newcastle, Liver Res Ctr, Sch Clin Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Univ Newcastle Newcastle Upon Tyne Tyne & Wear England NE2 4HH
Citazione:
P.T. Donaldson et al., "HLA class II alleles in Chinese patients with hepatocellular carcinoma", LIVER, 21(2), 2001, pp. 143-148

Abstract

Background/Aims: Recent reports of an association between human leucocyte antigens (HLA) and persistence of hepatitis B virus infection, and the familial clustering of hepatocellular carcinoma raise the question of genetic susceptibility Previous studies have been limited to serological phenotypingof HLA B and DR antigens. The aim of this study was to use molecular genotyping to investigate HLA class II as a risk factor for the development of hepatocellular wt-cinema in Hong Kong Chinese. Methods. We determined HLA DRB1, DQA1, DQB1 and DPB1 alleles in 123 hepatitis B surface antigen positivepatients (84 with hepatocellular carcinoma and 39 without) and 124 matchedcontrols. Results: The alleles DRB1*1501 (36% of HCC patients ver sus 19% of controls, odds ratio = 2.44), DQA1*0.102 (42% versus 76%, odds ratio=2.07), and DPB1*0501 (80% versus 63%, odds rsttio-2.35) were significantly more common in patients with hepatocellular carcinoma, and DQA1*03 (36% versus56%, odds ratio=0.53), DQB1*0302 (4.% versus 13%, odds ratio=0.25) and DPB1*0201 (14% versus 29%, odds ratio=0.4) were found at significantly lower frequencies. Conclusions: Although none of these associations was significant after correction for multiple testing, this report suggests that further investigations are warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:17:15