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Titolo:
Enhanced expression of endothelin receptor subtypes in cirrhotic rat liver
Autore:
Yokomori, H; Oda, M; Ogi, M; Kamegaya, Y; Tsukada, N; Nakamura, M; Ishii, H;
Indirizzi:
Med Ctr Hosp, Dept Internal Med, Kitasato, Saitama, Japan Med Ctr Hosp Kitasato Saitama Japan ternal Med, Kitasato, Saitama, Japan Med Ctr Hosp, Pathol Lab, Kitasato, Saitama, Japan Med Ctr Hosp Kitasato Saitama Japan Pathol Lab, Kitasato, Saitama, Japan Univ Tokyo, Sch Med, Dept Internal Med, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 Sch Med, Dept Internal Med, Tokyo 113, Japan
Titolo Testata:
LIVER
fascicolo: 2, volume: 21, anno: 2001,
pagine: 114 - 122
SICI:
0106-9543(200104)21:2<114:EEOERS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL-HYPERTENSION; STELLATE CELLS; B RECEPTOR; LIGHT; IMMUNOHISTOCHEMISTRY; CONTRACTILITY; PHYSIOLOGY; LIPOCYTES; FIBROSIS; PRESSURE;
Keywords:
immunogold electron microscopy immunohistochemistry; sinusoidal endothelial cell; hepatic stellate cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Yokomori, H Kitasato Inst Med Ctr Hosp, 121-1 Arai, Kitamotoshi, Saitama 3648501, Japan Kitasato Inst Med Ctr Hosp 121-1 Arai Kitamotoshi Saitama Japan 3648501
Citazione:
H. Yokomori et al., "Enhanced expression of endothelin receptor subtypes in cirrhotic rat liver", LIVER, 21(2), 2001, pp. 114-122

Abstract

Background/Aim: A number of vasoactive substances have been implicated as potential mediators of intrahepatic portal hypertension. Endothelin (ET)-1 has been suggested to be involved in the regulation of hepatic microcirculation and development of portal hypertension, The aim of this study was to clarify the localization of two subtypes of ET receptors, ET A (ErAR) anil Breceptors (ETBR), in normal rat liver, and how the receptor expressions are altered in CCl4-induced cirrhotic rat liver. Methods: Liver specimens were examined immunohistochemically after reacting with anti-ETAR and anti-ETBR rabbit polyclonal antibodies. Immunogold staining was also performed using the same antibodies, and examined under light and electron microscopy Results. In normal rat liver. immunohistochemistry revealed expression of ETARanti ETBR on the hepatic sinusoidal lining cells. By immunogold electron microscopy! electron-dense fold particles indicating the presence of ETARs were localized mainly on hepatic stellate cells (HSCs) and to a lesser extent on sinusoidal endothelial cells (SECs), while ETBRs were expressed equally intensely on HSCs and SECs. In cirrhotic animals, both ETAR and ETBR increased significantly on HSCs, while there were no significant increases in either receptor on SEC's, Conclusions. In the normal state, HSCs possess both ETARs acid ETBRs, while SECs mainly possess ETBRs. III cirrhosis, endothelins may exert more intense effects on HSCs via the enhanced ETARs and ETBRs, causing an increase in hepatic sinusoidal microvascular tone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:18:03