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Titolo:
Carcinoma of the external auditory canal and middle ear as an interdisciplinary challenge for otosurgery and radiotherapy.
Autore:
Schwager, K; Pfreundner, L; Hoppe, F; Baier, G; Willner, J; Baier, K;
Indirizzi:
Univ Wurzburg, Klin & Poliklin Hals Nasen & Ohrenkranke, D-97080 Wurzburg,Germany Univ Wurzburg Wurzburg Germany D-97080 nkranke, D-97080 Wurzburg,Germany
Titolo Testata:
LARYNGO-RHINO-OTOLOGIE
fascicolo: 4, volume: 80, anno: 2001,
pagine: 196 - 202
SICI:
1615-0007(200104)80:4<196:COTEAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
GER
Soggetto:
TEMPORAL BONE; MEATUS; MANAGEMENT;
Keywords:
carcinoma of the external auditory canal; middle ear carcinoma; surgery; radiotherapy; brachytherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Schwager, K Univ Wurzburg, Hals Nasen Ohren Klin, Josef Schneider Str 11, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-97080
Citazione:
K. Schwager et al., "Carcinoma of the external auditory canal and middle ear as an interdisciplinary challenge for otosurgery and radiotherapy.", LARY RH OTO, 80(4), 2001, pp. 196-202

Abstract

Carcinoma of the External Auditory Canal and Middle Ear as an Interdisciplinary Challenge for Otosurgery and Radiotherapy. Background: Carcinoma of the external auditory canal are tumours considered to have a poor prognosis. Improvement of the survival rate by surgical means alone is not possible. Individual therapy modalities as a result of an interdisciplinary approach between otosurgeon and radiotherapist are necessary. Patients and Methods: A series of 30 patients (3 patients pretreated at other institutions) with carcinoma of the external auditory canal and middle ear treated between 1978 and 1997 in our institutions was analysed with particular reference to tumour size and its relation to surrounding tissues, patterns of neck node involvement, surgical procedures, and radiation techniques. Clinical endpoints were freedom from local failure, overall survival, disease-free survival. The mean follow-up was 4.7 years (range: 0.1 to 18.8 years), median 3 years. Results: Treatment by surgery and radiotherapy resulted in an overall 5-year survival rate of 51%. According to Pittsburgh classification the 5-year survival rate for early disease (T1- and T2-tumours) was 89%, for stage III 67% and for stage IV 39%. Most important prognostic factors were dural infiltration (all patients with dural invasion died within 2.2 years) and the infiltration of surgical margins (the 5-year survival rate of patients with complete tumour resection was 100%, but 54% in patients with tumour beyond surgical margins). 192-iridium HDR afterloading brachytherapy, based on 3D CT-treatment planning is an effective tool in the management of local recurrences following surgery and a full course of external beam radiotherapy. Conclusions: Surgical resection followed by radiotherapy adapted to the stage of disease and grade of resection is the preferred treatment of cancerof the external auditory canal and middle ear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/02/20 alle ore 05:41:30