Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Sickness behaviour, an animal equivalent to human quality of life, is improved in septic rats by 6-CSF and antibiotic prophylaxis
Autore:
Bauhofer, A; Witte, K; Celik, I; Pummer, S; Lemmer, B; Lorenz, W;
Indirizzi:
Univ Marburg, Inst Theoret Surg, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 oret Surg, D-35033 Marburg, Germany Univ Heidelberg, Fac Clin Med Mannheim, Inst Pharmacol & Toxicol, D-68169 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68169 icol, D-68169 Mannheim, Germany
Titolo Testata:
LANGENBECKS ARCHIVES OF SURGERY
fascicolo: 2, volume: 386, anno: 2001,
pagine: 132 - 140
SICI:
1435-2443(200103)386:2<132:SBAAET>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; TUMOR-NECROSIS-FACTOR; OF-LIFE; MYOCARDIAL-INFARCTION; SEPSIS; MODEL; PERITONITIS; INFECTION; INTERLEUKIN-1-BETA; INFLAMMATION;
Keywords:
sickness behaviour; quality of life; locomotor activity; radio telemetry; sepsis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Bauhofer, A Univ Marburg, Inst Theoret Surg, Baldingerstr, D-35033 Marburg, Germany Univ Marburg Baldingerstr Marburg Germany D-35033 rg, Germany
Citazione:
A. Bauhofer et al., "Sickness behaviour, an animal equivalent to human quality of life, is improved in septic rats by 6-CSF and antibiotic prophylaxis", LANG ARCH S, 386(2), 2001, pp. 132-140

Abstract

Background and aim: New biological response modifiers are usually tested in reductionistic, pharmacological animal models by the determination of mechanistic endpoints (mortality rats, cellular/physiological parameters). In the meantime, quality of life had become an important endpoint in clinical trials but adequate animal experiments are very rare. The aim of this studywas to demonstrate alterations in the behavioural response of septic rats due to a prophylaxis with cytokine (G-CSF) plus antibiotics. Methods: Sickness behaviour (locomotor activity, circadian rhythms of blood pressure, heart rate and temperature) was determined by the use of radio telemetry. Complex animal experiments in rats were performed including anaesthesis, antibiotic and G-CSF prophylasis, volume substitution, laparotomy, contamination and infection with human faecal suspension and postoperative analgesia. Rt Results: Prior to infection, rats showed circadian rhythm in locomotor activity, blood pressure, heart rate and temperature. Sham operation did not alter these parameters significantly. Immediately after abdominal contamination and infection, locomotor activity was strongly reduced and circadian rhythm was lost in all parameters. Body temperature showed a continuous rise, peaking 38 h after infection. Untreated animals died in 63% (8/14) of cases. Antibiotic prophylaxis blunted the febrile response and markedly reduced mortality to 20% (2/10) or 0% (0/10) using G-CSF plus antibiotics. Blood pressure and heart rate were increased in parallel with the rise in temperature, These early physiologicol changes were not prevented by prophylaxis, but normal behaviour was restored faster with G-CSF plus antibiotic prophylaxis. Conclusions: In septic rats, sickness behaviour (locomotor activity) issignificantly improved in parallel to the mortality rate by a prophylasis with Cr-CSF plus antibiotics. Sickness behaviour can be considered as an equivalent to human quality of life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:53:13