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Titolo:
Prognostic importance of isolated peritumoral lymphangiosis carcinomatosa in lymph-node-negative colorectal carcinoma
Autore:
Meyer, W; Awad-Allah, A; Steinhauser, BB; Jurowich, C; Kaiser, A; Gebhardt, C;
Indirizzi:
Klinikum Nurnberg Nord, Dept Abdominal Thorac & Endocrine Surg, D-90419 Nurnberg, Germany Klinikum Nurnberg Nord Nurnberg Germany D-90419 -90419 Nurnberg, Germany Klinikum Nurnberg Nord, Inst Pathol, D-90419 Nurnberg, Germany Klinikum Nurnberg Nord Nurnberg Germany D-90419 -90419 Nurnberg, Germany
Titolo Testata:
LANGENBECKS ARCHIVES OF SURGERY
fascicolo: 2, volume: 386, anno: 2001,
pagine: 124 - 131
SICI:
1435-2443(200103)386:2<124:PIOIPL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; CLINICAL-SIGNIFICANCE; RECTAL-CARCINOMA; CANCER PATIENTS; COLON-CANCER; TUMOR-CELLS; MICROMETASTASES; LYMPHADENECTOMY; METASTASES; SURVIVAL;
Keywords:
colorectal cancer; prognostic factors; microinvasion; lymph-vessel invasion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, W Klinikum Nurnberg Nord, Dept Abdominal Thorac & Endocrine Surg, Prof ErnstNathan Str 1, D-90419 Nurnberg, Germany Klinikum Nurnberg Nord Prof Ernst Nathan Str 1 Nurnberg Germany D-90419
Citazione:
W. Meyer et al., "Prognostic importance of isolated peritumoral lymphangiosis carcinomatosa in lymph-node-negative colorectal carcinoma", LANG ARCH S, 386(2), 2001, pp. 124-131

Abstract

Background: The prognostic value of microinvasion of lymph vessels and lymph nodes has become increasingly important, there is a wide range in prognosis of patients with nodal-negative e tumor stages after curative resectionfor co-lorectal cancer. Aim: Detection of the prognostic importance of isolated lymph-vessel invasion as a possible precursor of lymph-node metastasis in patients with nodal-negative tumor stages. Patients/methods: Retrospective analysis of 894 patients with R0-resected colorectal cancer, uni- and multivariate analysis of tumorbiologic prognostic factors, immunohistochemical proof of tumor cells in negative lymph nodes (pN0) using the epithelialmarker HEA-125 (human epithelial antigen). Results: The incidence of lymph-vessel invasion (L) was 37.7% in total. A pN0,L1 status was found in 144 patients (16.1% of all analyzed patients). Comparing patients with pN0,L1 status to these with pN+,L0 status showed that both groups have similar rates of overall survival and tumor relapse. Lymph-node status, lymph-vessel invasion, depth of tumor infiltration (pT) stage? and age were detected as independent prognostic factors by multivariateanalysis. After reanalysis of 54 cases primarily classified as 18.5% pNO,LI, microinvasion in lymph nodes was detected by immunohistochemistry. We found a higher rate of tumor relapse (similar to 20%) for those patients. In regard to the overall survival rate, however, there was no difference when compared to patients without immunohistochemical pl oof of microinvasion. Conclusion: Isolated lymph-vessel invasion in nodal-negative tumor stages and a lymph-node-positive tumor status have equivalent prognostic importance in colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:37:48