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Titolo:
Absolute filling defects of the optic disc in fluorescein angiograms in glaucoma a retrospective clinical study
Autore:
Plange, N; Remky, A; Arend, O;
Indirizzi:
Univ Aachen, Augenklin, Rhein Westfal TH Aachen, D-52057 Aachen, Germany Univ Aachen Aachen Germany D-52057 al TH Aachen, D-52057 Aachen, Germany
Titolo Testata:
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
fascicolo: 4, volume: 218, anno: 2001,
pagine: 214 - 221
SICI:
0023-2165(200104)218:4<214:AFDOTO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
GER
Soggetto:
OPEN-ANGLE GLAUCOMA; SCANNING LASER OPHTHALMOSCOPY; NORMAL-TENSION GLAUCOMA; NERVE HEAD; RETINAL HEMODYNAMICS; NEUROPATHY; VELOCITY; DAMAGE;
Keywords:
primary open-angle glaucoma; normal-tension glaucoma; fluorescein-angiography; scanning laser ophthalmoscope; filling defect; optic nerve head;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Plange, N Univ Aachen, Augenklin, Rhein Westfal TH Aachen, Pauwelsstr 30, D-52057 Aachen, Germany Univ Aachen Pauwelsstr 30 Aachen Germany D-52057 achen, Germany
Citazione:
N. Plange et al., "Absolute filling defects of the optic disc in fluorescein angiograms in glaucoma a retrospective clinical study", KLIN MONATS, 218(4), 2001, pp. 214-221

Abstract

Background: Analysis of clinical importance of the size of filling defectsin fluorescein angiograms in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), ocular hypertension and subjects with physiological excavations in comparison to visual field loss, optic nerve head morphology and hemodynamics. Patients and Methods: 75 patients (POAG, NTG, ocular hypertension) and 10 healthy subjects with physiological excavations were included in this study. In digitized video fluorescein angiograms (Scanning Laser Ophthalmoscope)the size of absolute filling defects of the optic disc was quantified in the early venous phase and expressed by percentage of the optic disc. Visualfields were obtained by conventional static perimetry (Humphrey 24-2) and graded in stages of glaucoma visual field defects (Aulhorn I-V). Optic discexcavations were evaluated as cup-to-disc-area-ratios. Results: The filling defects correlated with the visual-field loss stages of Aulhorn and the visual field indices MD (mean deviation), PSD (pattern standard deviation) and CPSD (corrected pattern standard deviation). There was no correlation with the index SF (short-term fluctuation) and with systemic hemodynamics (blood pressure, perfusion pressure) or the IOP. Absolute filling defects correlated with the cup-to-disc-area-ratio in NTG. The absolute filling defects were larger in patients with glaucoma (POAG, NTG) in comparison to patients without glaucomatous visual field loss (ocular hypertension, glaucoma-like discs). No difference of filling defects was found inthe glaucoma group (POAG, NTG). Patients with NTG had larger excavations and lower systolic blood pressures than patients with POAG. Conclusion: The size of fluorescein filling defects may be useful as a parameter for the evaluation of an ischemic lesion of the optic nerve head. Absolute filling defects may differentiate POAG from ocular hypertension and NTG from glaucoma-like discs without field defects. The results support thehypothesis that in POAG and NTG disturbances of the circulation result in similar filling defects of the optic disc and visual field loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:32:44