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Titolo:
Effect of osaterone acetate administration on prostatic regression rate, peripheral blood hormone levels and semen quality in dogs with benign prostatic hypertrophy
Autore:
Tsutsui, T; Hori, T; Shimizu, M; Tatsuzawa, C; Kawakami, E;
Indirizzi:
Nippon Vet & Anim Sci Univ, Dept Reprod, Musashino, Tokyo 1808602, Japan Nippon Vet & Anim Sci Univ Musashino Tokyo Japan 1808602 o 1808602, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 4, volume: 63, anno: 2001,
pagine: 453 - 456
SICI:
0916-7250(200104)63:4<453:EOOAAO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLORMADINONE ACETATE; PELLET IMPLANTATION; ANTIANDROGEN; DISEASE; VOLUME;
Keywords:
canine BPH; osaterone acetate; prostatic volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Tsutsui, T Nippon Vet & Anim Sci Univ, Dept Reprod, 1-7-1 Kyonan Cho, Musashino, Tokyo 1808602, Japan Nippon Vet & Anim Sci Univ 1-7-1 Kyonan Cho Musashino Tokyo Japan 1808602
Citazione:
T. Tsutsui et al., "Effect of osaterone acetate administration on prostatic regression rate, peripheral blood hormone levels and semen quality in dogs with benign prostatic hypertrophy", J VET MED S, 63(4), 2001, pp. 453-456

Abstract

The effects of osaterone acetate (OSA), which is an anti-androgen agent being developed as a therapeutic drug for benign prostatic hypertrophy (BPH) in dogs, on the degree of prostatic regression and semen qualities were investigated. Prostatic regression was compared between dogs with and without orchidectomy. Five male beagles aged 5-9 years were used in the experiment. OSA was orally administered at doses; of 0.2 mg/kg and 0.5 mg/kg for one week. The prostatic regression rate one week after the end of administrationwas 62.6% on average. In the orchidectomized group, the mean regression rate one week after orchidectomy was 60.1%. However. the prostate became enlarged 6 months after administration, compared to the size prior to administration. The above Endings suggested that OSA is clinically applicable as a therapeutic drug for BPH in dogs, and inhibits prostatic hypertrophy during the early phase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:43:46