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Titolo:
Infectivity and pathological changes in murine clonorchiasis: Comparison in immunocompetent and immunodeficient mice
Autore:
Yoon, BI; Choi, YK; Kim, DY; Hyun, BH; Joo, KH; Rim, HJ; Lee, JH;
Indirizzi:
KCCH, Lab Expt Pathol, Seoul 139706, South Korea KCCH Seoul South Korea 139706 Lab Expt Pathol, Seoul 139706, South Korea Seoul Natl Univ, Coll Vet Med, Dept Vet Pathol, Suwon, South Korea Seoul Natl Univ Suwon South Korea , Dept Vet Pathol, Suwon, South Korea Korea Res Inst Biosci & Biotechnol, Taejon, South Korea Korea Res Inst Biosci & Biotechnol Taejon South Korea ejon, South Korea Korea Univ, Coll Med, Dept Parasitol, Seoul, South Korea Korea Univ Seoul South Korea ll Med, Dept Parasitol, Seoul, South Korea
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 4, volume: 63, anno: 2001,
pagine: 421 - 425
SICI:
0916-7250(200104)63:4<421:IAPCIM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPISTHORCHIS-VIVERRINI; SINENSIS INFECTION; LIVER; HAMSTERS;
Keywords:
Clonorchis sinensis; FVB; infectivity; SCID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JH KCCH, Lab Expt Pathol, 215-4 Gongneung Dong, Seoul 139706, South Korea KCCH 215-4 Gongneung Dong Seoul South Korea 139706 6, South Korea
Citazione:
B.I. Yoon et al., "Infectivity and pathological changes in murine clonorchiasis: Comparison in immunocompetent and immunodeficient mice", J VET MED S, 63(4), 2001, pp. 421-425

Abstract

The main complications of clonorchiasis are periportal inflammation, biliary hyperplasia, periductal fibrosis, and subsequently the development of biliary tumors in the liver. This study was undertaken to compare the infectivity and histopathologic changes between in immunocompetent FVB/NJ and BALB/cA strains, and immunodeficient severe combined immunodeficient (SCID) andathymic nude mice after the metacercariae of Clonorchis (C). sinensis wereinfected. The experiment showed that C. sinensis was very infective in allstrains studies, but the status of worm development. infectivity, recoveryrate, and morphological changes of livers were very different in each strain. FVB/NJ mice showed more worm recovery than any other strain. Histopathologically the liver of FVB/NJ mice at 4 weeks postinfection showed marked cystic and fibrotic changes, in which C. sinensis was fully developed with ovum production, severe infiltration of inflammatory cells, mostly eosinophils, and birth degrees of biliary hyperplasia. In SCID and nude mice, there were few foci of inflammatory cells even at 8 weeks postinfection in periportal areas of the liver, associated with no development into adult worm with ovum production. Fibrosis occurring at 4 weeks postinfection was highly correlated with inflammatory infiltration when each strain was compared. We suggest that massive infiltration of eosinophil and plasma cells caused by the infection might initiate cystic formation and fibrosis. These data demonstrate that the infection of C. sinensis might be related to pathologic consequences of inflammatory cell infiltration, cystic formation and fibrosiswhich might play a role in the defense mechanism against the parasitism inthe liver of each strain. The FVB/NJ mouse model might be very helpful in elucidating the mechanism for human clonorchiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:47:55