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Titolo:
Human visual function in the North Carolina Clinical Study on possible estuary-associated syndrome
Autore:
Hudnell, HK; House, D; Schmid, J; Koltai, D; Stopford, W; Wilkins, J; Savitz, DA; Swinker, M; Music, S;
Indirizzi:
US EPA, Natl Hlth & Environm Effects Res Lab, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 oxicol, Res Triangle Pk, NC 27711 USA US EPA, Biostat & Res Support Staff, Natl Hlth & Environm Effects Res Lab,Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 Res Lab,Res Triangle Pk, NC 27711 USA Duke Univ, Sch Med, Durham, NC USA Duke Univ Durham NC USADuke Univ, Sch Med, Durham, NC USA Univ N Carolina, Sch Med, Chapel Hill, NC USA Univ N Carolina Chapel HillNC USA arolina, Sch Med, Chapel Hill, NC USA Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA a, Sch Publ Hlth, Chapel Hill, NC USA E Carolina Sch Med, Greenville, NC USA E Carolina Sch Med Greenville NC USA arolina Sch Med, Greenville, NC USA N Carolina Dept Hlth & Human Serv, Raleigh, NC USA N Carolina Dept Hlth & Human Serv Raleigh NC USA n Serv, Raleigh, NC USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 8, volume: 62, anno: 2001,
pagine: 575 - 594
SICI:
1528-7394(20010420)62:8<575:HVFITN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORMER MICROELECTRONICS WORKERS; SPATIAL CONTRAST SENSITIVITY; PFIESTERIA-PISCICIDA; NUCLEAR CATARACTS; CIGARETTE-SMOKING; OPTIC NEUROPATHY; DEFICITS; VISION; FISH; DINOFLAGELLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Hudnell, HK US EPA, Natl Hlth & Environm Effects Res Lab, Div Neurotoxicol, MD-74B, Res Triangle Pk, NC 27711 USA US EPA MD-74B Res Triangle Pk NC USA 27711 le Pk, NC 27711 USA
Citazione:
H.K. Hudnell et al., "Human visual function in the North Carolina Clinical Study on possible estuary-associated syndrome", J TOX E H A, 62(8), 2001, pp. 575-594

Abstract

The U.S. Environmental Protection Agency assisted the North Carolina Department of Health and Human Services in conducting a study to investigate thepotential for an association between fish kills in the North Carolina estuary system and the risk for persistent health effects. Impetus for the study was recent evidence suggesting that estuarine dinoflagellates, including members of the toxic Pfiesteria complex (TPC), P. piscicida and P. schumwayae, may release a toxin(s) that kills fish and adversely affects human health. This report describes one component of the study in which visual systemfunction was assessed. Participants working primarily in estuaries inhabited by TPC or in offshore waters thought not to contain TPC were studied. The potentially exposed estuary (n = 22) and unexposed offshore (n = 20) workers were matched for age, gender, and education. Visual acuity did not differ significantly between the cohorts, but visual contrast sensitivity (VCS), an indicator of visual pattern-detection ability for stimuli of various sizes, was significantly reduced by about 30% in the estuary relative to theoffshore cohort. A further analysis that excluded participants having a history possibly predictive of neuropsychological impairment showed a similarVCS reduction. Additional analyses indicated that differences between the cohorts in age, education, smoking, alcohol consumption, and total time spent on anywater did not account for the difference in VCS. Exploratory analyses suggested a possible association between the magnitude of VCS reductionand hours spent in contact with a fish kill. The profile of VCS deficit across stimulus sizes resembled that seen in organic solvent-exposed workers,but an assess ment of occupational solvent and other neurotoxicant, exposures did not indicate differences between the cohorts. These results suggestthat factor(s) associated with the North Carolina estuaries, including thepossibility of exposure to TPC toxin(s), may impair visual system function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:13:09