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Titolo:
Effects of chronic sodium azide on brain and muscle cytochrome oxidase activity: A potential model to investigate environmental contributions to neurodegenerative diseases
Autore:
Berndt, JD; Callaway, NL; Gonzalez-Lima, F;
Indirizzi:
Univ Texas, Inst Neurosci, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Texas, Inst Neurosci, Austin, TX 78712 USA Univ Texas, Ctr Mol & Cellular Toxicol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 l & Cellular Toxicol, Austin, TX 78712 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 1, volume: 63, anno: 2001,
pagine: 67 - 77
SICI:
1528-7394(20010511)63:1<67:EOCSAO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-OXIDASE; MITOCHONDRIAL DYSFUNCTION; ALZHEIMERS-DISEASE; RAT-BRAIN; HISTOCHEMISTRY; INVOLVEMENT; DEPRIVATION; GENETICS; HYPOXIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzalez-Lima, F Univ Texas, Inst Neurosci, Merzes Hall 330, Austin, TX 78712 USA Univ Texas Merzes Hall 330 Austin TX USA 78712 78712 USA
Citazione:
J.D. Berndt et al., "Effects of chronic sodium azide on brain and muscle cytochrome oxidase activity: A potential model to investigate environmental contributions to neurodegenerative diseases", J TOX E H A, 63(1), 2001, pp. 67-77

Abstract

Deficits in oxidative phosphorylation have been implicated in many neurodegenerative diseases. In this study, cytochrome oxidase activity was inhibited following a 28-d systemic administration of nonlethal sodium azide via subcutaneous osmotic pumps. Quantitative enzyme histochemistry was performedon tissue sections from brain, skeletal muscle, and heart to localize cytochrome oxidase activity both globally and in regions within each tissue Significant decreases of cytochrome oxidase activity were found in the brain and skeletal muscle but not heart. In addition, regions within each tissue were also analyzed, such as cortex and striatum in the brain and red and white fibers in skeletal muscle. The tissue specific inhibition of cytochrome oxidase by sodium azide could serve as a positive control for studies of other mitochondrial toxins in aerobically compromised cells. Therefore, chronic nonlethal sodium azide administration may provide a potential rat model for the study of mitochondrial dysfunction and the role of environmental pollutants in brain and muscle tissues affected in certain neurodegenerative diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:07:37