Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lack of effect of psychosocial stress on maternal corticotropin-releasing factor and catecholamine levels at 28 weeks' gestation
Autore:
Petraglia, F; Hatch, MC; Lapinski, R; Stomati, M; Reis, FM; Cobellis, L; Berkowitz, GS;
Indirizzi:
Univ Siena, Policlin Scotte, Chair Obstet & Gynecol, Dept Obstet & Gynecol, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 pt Obstet & Gynecol, I-53100 Siena, Italy Mt Sinai Med Ctr, Dept Community & Prevent Med, Div Epidemiol, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 Epidemiol, New York, NY 10029 USA Mt Sinai Med Ctr, Dept Obstet & Gynecol, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 & Gynecol, New York, NY 10029 USA
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 2, volume: 8, anno: 2001,
pagine: 83 - 88
SICI:
1071-5576(200103/04)8:2<83:LOEOPS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; PRETERM DELIVERY; HUMAN-PREGNANCY; HUMAN-PLACENTA; BETA-ENDORPHIN; HORMONE; PLASMA; SECRETION; ASSOCIATIONS; PARTURITION;
Keywords:
corticotropin-releasing factor; pregnancy; psychosocial stress; cortisol; catecholamines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Petraglia, F Univ Siena, Policlin Scotte, Chair Obstet & Gynecol, Dept Obstet & Gynecol, Viale Bracci, I-53100 Siena, Italy Univ Siena Viale Bracci Siena Italy I-53100 100 Siena, Italy
Citazione:
F. Petraglia et al., "Lack of effect of psychosocial stress on maternal corticotropin-releasing factor and catecholamine levels at 28 weeks' gestation", J SOC GYN I, 8(2), 2001, pp. 83-88

Abstract

OBJECTIVE: Corticotropin-releasing factor (CRF) and catecholamines are among the major hormones activated during the adaptive response to stressful stimuli. In pregnant women, serum CRF and catecholamines levels increase during labor and preterm delivery. The aim of the present study was to evaluate whether psychosocial stress measures are correlated with serum CRF or urinary catecholamine [ie, epinephrine, norepinephrine (NE), dopamine (DA)] levels in healthy midtrimester pregnant women. METHODS: A large group of white pregnant women (n = 382) participated in the present study. The Work Conditions Questionnaire and the Psychiatric Epidemiology Research Interview were administered to measure job stress and general life stress, respectively. Urine and blood specimens were collected at 28 weeks of gestation at the time of psychosocial evaluation. Epinephrine, NE, and DA were quantified in the urine by a highly sensitive method based on an amperometric detector. Serum CRF and cortisol levels were measured in blood specimens by using specific radioimmunoassays. RESULTS: Serum CRF and cortisol levels did not vary between patients with high and low scores on psychological tests, and no correlation was found between CRF and cortisol levels. One job stress measure, low job latitude, was significantly associated with a mild increase in NE and DA levels in the afternoon and night (P <. 05, analysis of variance). Serum cortisol levels were inversely correlated with NE in the morning (r = -0.447; P = .002) andnight segments (r = -0.391; P = .007) and with DA in the night period (r =-0.367; P = .013). CONCLUSION: The absence of a significant relationship between CRF/cortisoland psychosocial stress measures in pregnant women suggests that the hypothalamic-pituitary-adrenal response to psychosocial stress may be masked at midtrimester by the constantly high levels of placental CRF, whose control is beyond the influence of environmental stressors. Copyright (C) 2001 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 18:19:04