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Titolo:
Brain activation on fMRI and verbal memory ability: Functional neuroanatomic correlates of CVLT performance
Autore:
Johnson, SC; Saykin, AJ; Flashman, LA; McAllister, TW; Sparling, MB;
Indirizzi:
Dartmouth Med Sch, Dept Psychiat, Brain Imaging Lab, Lebanon, NH 03756 USADartmouth Med Sch Lebanon NH USA 03756 Imaging Lab, Lebanon, NH 03756 USA Dartmouth Med Sch, Dept Radiol, Lebanon, NH 03756 USA Dartmouth Med Sch Lebanon NH USA 03756 Dept Radiol, Lebanon, NH 03756 USA New Hampshire Hosp, Concord, NH 03301 USA New Hampshire Hosp Concord NH USA 03301 shire Hosp, Concord, NH 03301 USA
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 1, volume: 7, anno: 2001,
pagine: 55 - 62
SICI:
1355-6177(200101)7:1<55:BAOFAV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MEDIAL TEMPORAL LOBES; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; EPISODIC MEMORY; RETRIEVAL SUCCESS; PET; MRI; RECOGNITION; HIPPOCAMPUS;
Keywords:
functional MRI; verbal memory; hippocampus; CVLT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Saykin, AJ Dartmouth Hitchcock Med Ctr, Brain Imaging Lab, Lebanon, NH 03756 USA Dartmouth Hitchcock Med Ctr Lebanon NH USA 03756 NH 03756 USA
Citazione:
S.C. Johnson et al., "Brain activation on fMRI and verbal memory ability: Functional neuroanatomic correlates of CVLT performance", J INT NEURO, 7(1), 2001, pp. 55-62

Abstract

We have recently reported (Saykin et al., 1999b) selective activation of left medial temporal lobe structures during processing of novel compared to familiar words using functional magnetic resonance imaging (fMRI). The current study describes the relationship between a widely used clinical test ofverbal learning, the California Verbal Learning Test (CVLT), and the previously reported fMRI activations. Thirteen right-handed healthy adult participants were studied with whole brain echo-planar fMRI while listening to novel and recently learned (familiar) words intermixed pseudorandomly in an event-related design. These participants were also tested with the CVLT Scores for CVLT Trial 1 (immediate encoding of novel words) and recognition discriminability (recognition of familiar vs, novel words) were correlated with fMRI signal change during processing of novel versus familiar words usinga covariance model implemented in SPM96. For the novel words analysis, voxels in the right anterior hippocampus correlated significantly with Trial 1(r = .76 at the maxima). For the recognition analysis, a significant cluster of voxels was found in the right dorsolateral prefrontal cortex (r = .88at the maxima). Our prior results of separable left medial temporal activation to novel and familiar words, together with results of the covariance analyses reported here, suggest that in addition to the left medial temporallobe (MTL) regions that are engaged during novel and familiar word processing, the right hippocampus and right frontal lobe are also involved, particularly in those participants with better memory ability. This positive relationship between fMRI activation and CVLT performance suggests a role for these right hemisphere regions in successful memory processing of verbal material, perhaps reflecting more efficient encoding and retrieval strategies that facilitate memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:07:35