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Titolo:
Selective deficits in verbal working memory associated with a known genetic etiology: The neuropsychological profile of Duchenne muscular dystrophy
Autore:
Hinton, VJ; De Vivo, DC; Nereo, NE; Goldstein, E; Stern, Y;
Indirizzi:
Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Scottish Rite Childrens Med Ctr, Dept Neurol, Atlanta, GA USA Scottish Rite Childrens Med Ctr Atlanta GA USA t Neurol, Atlanta, GA USA
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 1, volume: 7, anno: 2001,
pagine: 45 - 54
SICI:
1355-6177(200101)7:1<45:SDIVWM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MENTAL-RETARDATION; CEREBRAL-CORTEX; BRAIN; ATROPHY; LOCALIZATION; PERFORMANCE; INVOLVEMENT; HIPPOCAMPUS; EXPRESSION;
Keywords:
Duchenne Muscular Dystrophy; cognitive profile; dystrophin; developmental disability; working memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Hinton, VJ Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, P&S Box 16,630 W 168th St, New York, NY 10032 USA Columbia Univ Coll Phys & Surg P&S Box 16,630 W 168th St New York NY USA 10032
Citazione:
V.J. Hinton et al., "Selective deficits in verbal working memory associated with a known genetic etiology: The neuropsychological profile of Duchenne muscular dystrophy", J INT NEURO, 7(1), 2001, pp. 45-54

Abstract

Forty-one boys diagnosed with Duchenne muscular dystrophy (DMD) were each compared to an unaffected sibling on a battery of neuropsychological tests. Verbal, visuospatial, attention/memory, abstract thinking, and academic achievement skills were tested. Results indicated the boys with DMD performedsimilarly to their siblings on the majority of measures, indicating intactverbal, visuospatial, long-term memory, and abstract skills. However, the DMD group did significantly more poorly than their siblings on specific measures of story recall, digit span, and auditory comprehension, as well as in all areas of academic achievement (reading, writing, and math). This profile indicates that verbal working memory skills are selectively impaired inDMD, and that that likely contributes to limited academic achievement. Theassociation between the known impact of the genetic mutation on the development of the central nervous system and boys cognitive profile is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 08:56:34