Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation
Autore:
Llorente, AM; Van Gorp, WG; Stern, MJ; George, L; Satz, P; Marcotte, TD; Calvillo, GM; Hinkin, CH;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Vet Affairs Med Ctr, W Los Angeles, CA USA Vet Affairs Med Ctr W Los Angeles CA USA Med Ctr, W Los Angeles, CA USA Cornell Univ, Weill Med Coll, New York, NY 10065 USA Cornell Univ New York NY USA 10065 Weill Med Coll, New York, NY 10065 USA
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 1, volume: 7, anno: 2001,
pagine: 27 - 32
SICI:
1355-6177(200101)7:1<27:LEOHZT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS DEMENTIA COMPLEX; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CONTROLLED TRIAL; VIRUS INFECTION; THERAPY; DISEASE;
Keywords:
HIV-1; prolonged AZT administration; neuropsychological outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Llorente, AM Baylor Coll Med, Dept Psychiat & Behav Sci, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 77030 USA
Citazione:
A.M. Llorente et al., "Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation", J INT NEURO, 7(1), 2001, pp. 27-32

Abstract

This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B,WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-L seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program #298). Neither short-term (0-6 months) nor long-term (0-12 months) AZT administration revealed enhancement in NP performance. Theresults suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:02:32