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Titolo:
Electrochemical oxidation of guanosine-5 '-monophosphate at the pyrolytic graphite electrode
Autore:
Goyal, RN; Puri, BK; Jain, N;
Indirizzi:
Univ Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India Univ Roorkee Roorkee Uttar Pradesh India 247667 667, Uttar Pradesh, India Indian Inst Technol, Dept Chem, New Delhi 110016, India Indian Inst Technol New Delhi India 110016 Chem, New Delhi 110016, India
Titolo Testata:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
fascicolo: 5, , anno: 2001,
pagine: 832 - 837
SICI:
1472-779X(2001):5<832:EOOG'A>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUANOSINE 5'-MONOPHOSPHATE; ENZYMATIC OXIDATION; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Goyal, RN Univ Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India Univ Roorkee Roorkee Uttar Pradesh India 247667 Pradesh, India
Citazione:
R.N. Goyal et al., "Electrochemical oxidation of guanosine-5 '-monophosphate at the pyrolytic graphite electrode", J CHEM S P2, (5), 2001, pp. 832-837

Abstract

The electrochemical oxidation of guanosine-5'-monophosphate has been investigated in phosphate containing supporting electrolytes at pH 2.5-10.8 at apyrolytic graphite electrode by cyclic sweep voltammetry, spectral studies, controlled potential electrolysis and related techniques. The initial course of the electrode reaction has been deduced to involve a pH dependent 4e, 4H(+) oxidation to give a diimine species which undergoes a series of chemical reactions to give different products. The kinetics of the decay of the UV-absorbing intermediate generated during electrooxidation has been studied at different pH values and first-order rate constants for the disappearance of the UV-absorbing intermediate have been calculated. The electrooxidation of guanosine-5'-monophosphate has been found to be an EC reaction (electrode reaction followed by chemical reactions) in which charge transfer is followed by competitive chemical reactions. The ultimate products of oxidation, urea riboside phosphate, alloxan (pyrimidine-2,4,5,6(1H,3H)-tetraone) and a dimer were characterized by IR, H-1 NMR and mass spectrometry at pH3.4. A detailed interpretation of the redox mechanism for the formation ofthese products is presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:31:23