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Titolo:
CLINICAL AND PATHOLOGICAL CHARACTERIZATION OF NORTHERN ELEPHANT SEAL SKIN-DISEASE
Autore:
BECKMEN KB; LOWENSTINE LJ; NEWMAN J; HILL J; HANNI K; GERBER J;
Indirizzi:
UNIV ALASKA,INST ARCTIC BIOL,311 IRVING I FAIRBANKS AK 99775 MARINE MAMMAL CTR,GOLDEN GATE NATL RECREAT AREA SAUSALITO CA 94965 UNIV CALIF DAVIS,SCH VET MED,DEPT PATHOL MICROBIOL & IMMUNOL DAVIS CA95616 UNIV CALIF SANTA CRUZ,INST MARINE SCI,LONG MARINE LAB SANTA CRUZ CA 95060 TEXAS A&M UNIV,TEXAS VET MED CTR COLLEGE STN TX 77843
Titolo Testata:
Journal of wildlife diseases
fascicolo: 3, volume: 33, anno: 1997,
pagine: 438 - 449
SICI:
0090-3558(1997)33:3<438:CAPCON>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE METABOLISM; PHOCA-VITULINA; HARBOR SEAL; VITAMIN-A; POLYCHLORINATED BIPHENYL; ORGANOCHLORINE COMPOUNDS; HEAVY-METALS; POLLUTION; BLUBBER; FINLAND;
Keywords:
NORTHERN ELEPHANT SEAL; MIROUNGA ANGUSTIROSTRIS; HYPERKERATOSIS; SQUAMOUS METAPLASIA; ULCERATIVE DERMATITIS; SKIN DISEASE; PCB; DDT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
K.B. Beckmen et al., "CLINICAL AND PATHOLOGICAL CHARACTERIZATION OF NORTHERN ELEPHANT SEAL SKIN-DISEASE", Journal of wildlife diseases, 33(3), 1997, pp. 438-449

Abstract

From 1984 through 1992, staff at The Marine Mammal Center (TMMC, Sausalito, California, USA) examined 207 northern elephant seals (Miroungaangustirostris) with a condition of unknown etiology called northern elephant seal skin disease (NESSD). The skin lesions were characterized by patchy to extensive alopecia and hyperpigmentation, punctate or coalescing epidermal ulceration, and occasionally, massive skin necrosis. Microscopic lesions included ulcerative dermatitis with hyperkeratosis, squamous metaplasia and atrophy of sebaceous glands. All diseasedseals were less than 2 years of age and suffered from emaciation, depression, and dehydration. Mortality from septicemia increased significantly with severity of skin ulceration. Compared to 14 apparently unaffected seals, diseased seals had depressed levels of circulating thyroxine, triiodothyronine, retinol, serum iron, albumin, calcium, and cholesterol. Levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, gamma glutamyl transpeptidase, blood urea nitrogen, and uric acid were elevated. Morphometrically, diseased animals were approximately 15% smaller than normal seals of the same age. Serum and blubber concentrations of 36 polychlorinated biphenyl congeners (Sigma PCB) and dichloro-diphenyl-dichloroethylene (p,p'-DDE) were negatively correlated with body mass. Mean concentrations of Sigma PCBand p,p'-DDE in serum in diseased seals were elevated as compared to apparently normal seals. Etiology of this syndrome remains unknown, but the possibility of PCB toxicosis cannot be ruled out.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 12:48:04