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Titolo:
Permeation enhancement of a highly lipophilic drug using supersaturated systems
Autore:
Moser, K; Kriwet, K; Froehlich, C; Naik, A; Kalia, YN; Guy, RH;
Indirizzi:
Univ Geneva, Pharm Galen Lab, CH-1211 Geneva, Switzerland Univ Geneva Geneva Switzerland CH-1211 Lab, CH-1211 Geneva, Switzerland Novartis Pharma AG, Tech R&D PHAD, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland Ctr Interuniv Rech & Enseignement, F-74166 Archamps, France Ctr Interuniv Rech & Enseignement Archamps France F-74166 champs, France
Titolo Testata:
JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 5, volume: 90, anno: 2001,
pagine: 607 - 616
SICI:
0022-3549(200105)90:5<607:PEOAHL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATR-FTIR SPECTROSCOPY; HUMAN STRATUM-CORNEUM; TRADITIONAL DIFFUSION CELLS; VITRO MEMBRANE-TRANSPORT; IN-VITRO; HUMAN SKIN; SYNTHETIC MEMBRANES; HYDROCORTISONE ACETATE; TRANSDERMAL DELIVERY; NIFEDIPINE TRANSPORT;
Keywords:
supersaturation; skin permeation; topical delivery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Guy, RH Univ Geneva, Pharm Galen Lab, CH-1211 Geneva, Switzerland Univ Geneva Geneva Switzerland CH-1211 -1211 Geneva, Switzerland
Citazione:
K. Moser et al., "Permeation enhancement of a highly lipophilic drug using supersaturated systems", J PHARM SCI, 90(5), 2001, pp. 607-616

Abstract

The potential of supersaturation as a method for enhancing the membrane permeation of highly lipophilic compounds has been investigated using, as a model system, the transport of a lavendustin derivative (LAP, log K-o/w = 5)through silicone membrane. Propylene glycol-water mixtures, which permitted the formulation of LAP at different levels of saturation, were prepared and tested for stability prior to conducting membrane permeation studies. The transport of LAP across silicone membrane from donor solutions containingthe drug at different degrees of saturation (DS = 1-5) was evaluated by two independent experimental methods: iii using attenuated total-reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and (ii) using standard vertical diffusion cells followed by quantification with highperformance liquid chromatography (HPLC). Both methods demonstrated a linear relationshipbetween the DS of the applied solution and the flux through the membrane, yielding similar values for the diffusion coefficients of LAP (diffusion cells, D = 1.75 (+/- 0.16) x 10(-7) cm(2) s(-1) and ATR-FTIR, D = 1.42 (+/- 0.26) x 10(-7) cm(2) s(-1)). In addition to the characterization of LAP permeation, ATR-FTIR spectroscopy enabled an examination of solvent transport across the membrane. (C) 2001 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 90:607-616, 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:01:03