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Titolo:
Inhibitory effect of neuropeptide Y on morphine withdrawal is accompanied by reduced c-fos expression in specific brain regions
Autore:
Clausen, TR; Moller, M; Woldbye, DPD;
Indirizzi:
Univ Copenhagen, Dept Pharmacol, Lab Neuropsychiat, Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark b Neuropsychiat, Copenhagen, Denmark Univ Copenhagen, Inst Med Anat, Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark , Inst Med Anat, Copenhagen, Denmark
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 64, anno: 2001,
pagine: 410 - 417
SICI:
0360-4012(20010515)64:4<410:IEONYO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIAQUEDUCTAL GRAY-MATTER; OPIATE WITHDRAWAL; LOCUS-COERULEUS; RAT-BRAIN; PANCREATIC-POLYPEPTIDE; Y5-LIKE RECEPTORS; GENE-EXPRESSION; FOOD-INTAKE; PEPTIDE-YY; INDUCTION;
Keywords:
neuropeptide Y (NPY); morphine withdrawal; opioid addiction; c-fos;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Clausen, TR Novo Nordisk AS, Novo Nordisk Pk,G8-1-25, DK-2760 Malov, Denmark Novo Nordisk AS Novo Nordisk Pk,G8-1-25 Malov Denmark DK-2760
Citazione:
T.R. Clausen et al., "Inhibitory effect of neuropeptide Y on morphine withdrawal is accompanied by reduced c-fos expression in specific brain regions", J NEUROSC R, 64(4), 2001, pp. 410-417

Abstract

Neuropeptide Y (NPY) was previously shown in our laboratory to attenuate behavioral signs of morphine withdrawal. To further characterize the anti-withdrawal effect of NPY, the present study attempted to identify specific brain regions where NPY inhibits neuronal activity during withdrawal. Morphine dependence was induced in male Wistar rats by two daily subcutaneous injections of morphine at increasing doses, and the withdrawal syndrome was precipitated acutely by intraperitoneal administration of naloxone. Rats were pre-treated with an intracerebroventricular (icv) injection of NPY (12 nmol) or vehicle 30 min before the naloxone challenge. Withdrawal behavior was quantified using a point scoring technique based on motor- and non-motor-related signs. Brain areas involved in the attenuation of morphine withdrawalwere delineated by radioactive in situ hybridization for the immediate early gene c-fos, which is a marker for neuronal activity. The present study confirmed the inhibitory effect of NPY on withdrawal behavior. Inhibition ofbehavioral signs of naloxone-precipitated morphine withdrawal was accompanied by significantly reduced c-fos expression in the locus coeruleus, lateral septal nucleus, ventral part of the periaqueductal grey, cingulate and frontal cortices, and septohippocampal nucleus. Our data suggest that neo- and allo-cortical areas as well as specific brainstem nuclei are involved inthe anti-withdrawal effects of NPY. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:49:42