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Titolo:
Neurofilaments of Klotho, the mutant mouse prematurely displaying symptomsresembling human aging
Autore:
Uchida, A; Komiya, Y; Tashiro, T; Yorifuji, H; Kishimoto, T; Nabeshima, Y; Hisanaga, S;
Indirizzi:
Tokyo Metropolitan Univ, Grad Sch Sci, Dept Biol Sci, Hachioji, Tokyo 1920397, Japan Tokyo Metropolitan Univ Hachioji Tokyo Japan 1920397 Tokyo 1920397, Japan Tokyo Inst Technol, Fac Biosci, Lab Cell & Dev Biol, Yokohama, Kanagawa 227, Japan Tokyo Inst Technol Yokohama Kanagawa Japan 227 ohama, Kanagawa 227, Japan Gunma Univ, Sch Med, Dept Mol & Cellular Neurobiol, Maebashi, Gumma, JapanGunma Univ Maebashi Gumma Japan llular Neurobiol, Maebashi, Gumma, Japan Natl Def Med Coll, Dept Anat, Tokorozawa, Saitama, Japan Natl Def Med Coll Tokorozawa Saitama Japan t, Tokorozawa, Saitama, Japan Kyoto Univ, Inst Mol & Cellular Biol, Kyoto, Japan Kyoto Univ Kyoto Japan oto Univ, Inst Mol & Cellular Biol, Kyoto, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 64, anno: 2001,
pagine: 364 - 370
SICI:
0360-4012(20010515)64:4<364:NOKTMM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLOW AXONAL-TRANSPORT; NF-M; CYTOSKELETAL PROTEINS; MOTOR-NEURONS; RADIAL GROWTH; SUBUNIT; MICE; MATURATION; DEFICIENT; EXISTENCE;
Keywords:
neurofilament; aging; axonal transport; NF-M; Klotho;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hisanaga, S Tokyo Metropolitan Univ, Grad Sch Sci, Dept Biol Sci, 1-1 Minami Ohsawa, Hachioji, Tokyo 1920397, Japan Tokyo Metropolitan Univ 1-1 Minami Ohsawa Hachioji Tokyo Japan 1920397
Citazione:
A. Uchida et al., "Neurofilaments of Klotho, the mutant mouse prematurely displaying symptomsresembling human aging", J NEUROSC R, 64(4), 2001, pp. 364-370

Abstract

We reported previously that neurofilaments (NFs) of aged rats were highly packed in the axon and contained a smaller amount of NF-M as compared with those of young rats (Uchida et al. [1999] J. Neurosci. Res. 58,337-348), Westudied NFs of the mutant mouse, named Klotho, which displays prematurely symptoms resembling human aging. The transport of axonal cytoskeletal proteins, including NFs, tubulin and actin, was decreased at the leading portionof the peak of transported proteins in Klotho during the process of premature aging. The nearest neighbor inter-NF distance in Klotho axone (35-39 nm) was shorter than that of the wild-type mouse (48-49 nm), indicating the packing of NFs in Klotho. The ratio of NF-M to NF-L was slightly decreased in cytoskeletons from the spinal cords of Klotho. These changes ave similar,though not identical, to those observed in aged rats, and are the first evidence of age-related changes in the neurons of Klotho. (C) 2001 Wiley-Liss,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 22:00:51