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Titolo:
Pituitary control of BK potassium channel function and intrinsic firing properties of adrenal chromaffin
Autore:
Lovell, PV; McCobb, DP;
Indirizzi:
Cornell Univ, Dept Neurobiol & Behav, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Neurobiol & Behav, Ithaca, NY 14853 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 10, volume: 21, anno: 2001,
pagine: 3429 - 3442
SICI:
0270-6474(20010515)21:10<3429:PCOBPC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; CA2+-ACTIVATED K+ CHANNELS; MESSENGER-RNA; BETA-SUBUNIT; ADRENOCORTICOTROPIC HORMONE; MOLECULAR-BASIS; HAIR-CELLS; INACTIVATION; VOLTAGE; STRESS;
Keywords:
hypophysectomy; BK channels; chromaffin cells; action potentials; adrenal medulla; catecholamines; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: McCobb, DP Cornell Univ, Dept Neurobiol & Behav, W153 Mudd Hall, Ithaca, NY 14853 USA Cornell Univ W153 Mudd Hall Ithaca NY USA 14853 a, NY 14853 USA
Citazione:
P.V. Lovell e D.P. McCobb, "Pituitary control of BK potassium channel function and intrinsic firing properties of adrenal chromaffin", J NEUROSC, 21(10), 2001, pp. 3429-3442

Abstract

The discovery that the hypothalamic-pituitary-adrenocortical (HPA) endocrine stress axis controls an alternative splicing decision in chromaffin Slo-encoded BK (big potassium) channels raised the possibility that activation of the HPA could serve as a mechanism to tune the intrinsic electrical properties of epinephrine-secreting adrenal chromaffin cells. To test this, we compared BK functional properties and cell excitability in chromaffin cellsfrom normal and hypophysectomized (pituitary-ablated) rats. Hypophysectomywas found to alter the voltage dependence and kinetics of BK gating, making channels less accessible for activation from rest. Perforated-patch recordings revealed changes in action potential waveform and repetitive firing properties. The maximum number of spikes that could be elicited with a 2 secdepolarizing current pulse was reduced by similar to 50% by hypophysectomy. The results indicate that pituitary hormones can adapt the mechanics of adrenal catecholamine release by tailoring BK channel function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:37:24