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Titolo:
High-fidelity transmission acquired via a developmental decrease in NMDA receptor expression at an auditory synapse
Autore:
Futai, K; Okada, M; Matsuyama, K; Takahashi, T;
Indirizzi:
Univ Tokyo, Fac Med, Dept Neurophysiol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 , Dept Neurophysiol, Tokyo 1130033, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 10, volume: 21, anno: 2001,
pagine: 3342 - 3349
SICI:
0270-6474(20010515)21:10<3342:HTAVAD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
KITTEN VISUAL-CORTEX; D-ASPARTATE RECEPTOR; MEDIAL NUCLEUS; TRAPEZOID BODY; BRAIN-STEM; DEVELOPING CEREBELLUM; CURRENTS; CHANNEL; SUBUNIT; NEURONS;
Keywords:
NMDA receptor; high-fidelity synaptic transmission; postnatal development; the calyx of Held; cochlear ablation; excitatory postsynaptic current; AMPA receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, T Univ Tokyo, Fac Med, Dept Neurophysiol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 hysiol, Tokyo 1130033, Japan
Citazione:
K. Futai et al., "High-fidelity transmission acquired via a developmental decrease in NMDA receptor expression at an auditory synapse", J NEUROSC, 21(10), 2001, pp. 3342-3349

Abstract

Central auditory relay synapses in mature animals follow high-frequency inputs for computation of sound localization. In immature mice, however, transmission at the calyx of Held synapse in auditory brainstem was inaccurate for high-frequency inputs because the summed slow synaptic potential components caused aberrant firings or blocked action potentials. As the mice matured, synaptic potentials became shorter, with smaller and faster NMDA receptor components, thereby establishing the precise one-to-one transmission for high-frequency inputs. Developmental acquisition of this high-fidelity transmission could be mimicked experimentally in immature mice by blocking NMDA receptors with D(-)2-amino-5-phosphonovaleric acid (D-APV). Furthermore,bilateral cochlear ablations at postnatal day 7 (P7) attenuated the developmental decrease of NMDA receptor expression and prevented the acquisition of high-fidelity transmission. We suggest that auditory activity, which begins at P10-P12 in mice, downregulates the expression of postsynaptic NMDA receptors, thereby contributing to the establishment of high-fidelity synaptic transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:08:51