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Titolo:
Action potential bursting in subicular pyramidal neurons is driven by a calcium tail current
Autore:
Jung, HY; Staff, NP; Spurston, N;
Indirizzi:
Northwestern Univ, Inst Neurosci, Dept Neurobiol & Physiol, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 & Physiol, Evanston, IL 60208 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 10, volume: 21, anno: 2001,
pagine: 3312 - 3321
SICI:
0270-6474(20010515)21:10<3312:APBISP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED EPILEPTIFORM ACTIVITY; SPIKE AFTER-DEPOLARIZATION; IN-VITRO; ENTORHINAL CORTEX; RAT HIPPOCAMPAL; T-TYPE; PHARMACOLOGICAL PROPERTIES; ALZHEIMERS-DISEASE; CELLULAR MECHANISM; PACEMAKER NEURONS;
Keywords:
Ca2+ currents; HVA channels; bursting mechanism; subiculum; hippocampus; patch clamp;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Spurston, N Northwestern Univ, Inst Neurosci, Dept Neurobiol & Physiol, 2153 N Campus Dr, Evanston, IL 60208 USA Northwestern Univ 2153 N Campus Dr Evanston IL USA 60208 8 USA
Citazione:
H.Y. Jung et al., "Action potential bursting in subicular pyramidal neurons is driven by a calcium tail current", J NEUROSC, 21(10), 2001, pp. 3312-3321

Abstract

Subiculum is the primary output area of the hippocampus and serves as a key relay center in the process of memory formation and retrieval. A majorityof subicular pyramidal neurons communicate via bursts of action potentials, a mode of signaling that may enhance the fidelity of information transferand synaptic plasticity or contribute to epilepsy when unchecked. In the present study, we show that a Ca2+ tail current drives bursting in subicularpyramidal neurons. An action potential activates voltage-activated Ca2+ channels, which deactivate slowly enough during action potential repolarization to produce an afterdepolarization that triggers subsequent action potentials in the burst. The Ca2+ channels underlying bursting are located primarily near the soma, and the amplitude of Ca2+ tail currents correlates with the strength of bursting across cells. Multiple channel subtypes contributeto Ca2+ tail current, but the need for an action potential to produce the slow depolarization suggests a central role for high-voltage-activated Ca2channels in subicular neuron bursting.

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Documento generato il 25/01/20 alle ore 18:41:37