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Titolo:
The role of neuropeptide Y in orexin-induced hypothalamic-pituitary-adrenal activation
Autore:
Jaszberenyi, M; Bujdoso, E; Telegdy, G;
Indirizzi:
Univ Szeged, Dept Pathophysiol, Albert Szent Gyorgyi Med & Pharmaceut Ctr,MTA SZTE Neurohumoral Res Grp, H-6701 Szeged, Hungary Univ Szeged Szeged Hungary H-6701 umoral Res Grp, H-6701 Szeged, Hungary
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 438 - 441
SICI:
0953-8194(200105)13:5<438:TRONYI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; ADULT-RAT BRAIN; PARAVENTRICULAR NUCLEUS; ARCUATE NUCLEUS; IMMUNOREACTIVE INNERVATION; HYPOCRETIN OREXIN; LOCUS-COERULEUS; MESSENGER-RNA; FOOD-INTAKE; NEURONS;
Keywords:
hypothalamic-pituitary-adrenal system; neuropeptide Y; orexin-A; orexin-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Telegdy, G Univ Szeged, Dept Pathophysiol, Albert Szent Gyorgyi Med & Pharmaceut Ctr,MTA SZTE Neurohumoral Res Grp, Semmelwies 1, H-6701 Szeged, Hungary Univ Szeged Semmelwies 1 Szeged Hungary H-6701 Szeged, Hungary
Citazione:
M. Jaszberenyi et al., "The role of neuropeptide Y in orexin-induced hypothalamic-pituitary-adrenal activation", J NEUROENDO, 13(5), 2001, pp. 438-441

Abstract

The role of neuropeptide Y (NPY) in the mediation of orexin-induced hypothalamic-pituitary-adrenal (HPA) activation was investigated in the rat. The HPA system was stimulated by intracerebroventricular (i.c.v.) administration of orexin-A or orexin-B (140 or 280 pmol, respectively) and the plasma concentration of corticosterone was used as an index of the degree of activation. i.c.v. pretreatment with NPY antagonist or NPY antiserum (30 min or 24h before orexin administration, respectively) inhibited the orexin-inducedcorticosterone release. The inhibitory actions of the antagonist and the antiserum were revealed by the dose-response curve; the highest concentrations practically abolished the HPA activation evoked by the orexins. These data suggest that the HPA system-stimulating effect of the orexins may be mediated by NPY.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:33:58