Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotropin releasing factor and arginine vasopressin neurones in conscious rats
Autore:
Al-Barazanji, KA; Wilson, S; Baker, J; Jessop, DS; Harbuz, MS;
Indirizzi:
SmithKline Beecham Pharmaceut, Dept Vasc Biol, BRI, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD ssex, England Univ Bristol, URC Neuroendocrinol, Bristol, Avon, England Univ Bristol Bristol Avon England euroendocrinol, Bristol, Avon, England
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 421 - 424
SICI:
0953-8194(200105)13:5<421:COAHAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSITU HYBRIDIZATION HISTOCHEMISTRY; RECEPTOR MESSENGER-RNA; DIFFERENTIAL DISTRIBUTION; SPINAL-CORD; FOOD-INTAKE; STRESS; BRAIN; NEUROPEPTIDE; PHARMACOLOGY; RESPONSES;
Keywords:
ACTH; corticosterone; orexin-A; CRF mRNA; AVP mRNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Al-Barazanji, KA SmithKline Beecham Pharmaceut, Dept Vasc Biol, BRI, New Frontier Pk, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut New Frontier Pk Harlow Essex England CM19 5AD
Citazione:
K.A. Al-Barazanji et al., "Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotropin releasing factor and arginine vasopressin neurones in conscious rats", J NEUROENDO, 13(5), 2001, pp. 421-424

Abstract

The effects of centrally injected orexin-A on plasma adrenocorticotropin (ACTH) and corticosterone levels and corticotropin releasing factor (CRF) acid arginine vasopressin (AVP) mRNA in the parvocellular cells of the paraventricular nucleus (PVN) of the rat were investigated, In animals implanted previously with a lateral brain ventricle and femoral artery cannula, a single i.c.v. injection of orexin-A (10 mug/rat) resulted in a rapid, significant increase in plasma ACTH and corticosterone concentrations. Plasma ACTH reached a peak (12.5-fold greater than basal levels) at 30 min. which was maintained over 120 min before declining towards control levels by 240 min, Plasma corticosterone concentrations reached a peak (6.7-fold greater than basal levels) at 30 min. Orexin-A at a higher dose (30 mug/rat) also produced a rapid increase in plasma ACTH and corticosterone concentrations. The area under the curve for plasma levels of ACTH was similar for both doses oforexin-A, In a second study, orexin-A (10 mug/rat) was injected i.c.v. andbrains and pituitaries were rapidly removed after 240 min. In situ hybridization histochemistry revealed that CRF and AVP mRNA levels were significantly increased in the parvocellular cells of the PVN, Pro-opiomelanocortin mRNA levels in the pituitary gland were not significantly elevated in response to orexin-A. These results suggest that orexin-A is able to act centrally to activate the hypothalamic-pituitary-adrenal axis involving stimulationof both CRF and AVP expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 13:00:02