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Titolo:
Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
Autore:
Bader, J; Peters, J; Baltatu, O; Muller, DN; Luft, FC; Ganten, D;
Indirizzi:
Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany D-13092 D-13092 Berlin, Germany Franz Volhard Clin, D-13092 Berlin, Germany Franz Volhard Clin Berlin Germany D-13092 Clin, D-13092 Berlin, Germany Univ Heidelberg, Dept Pharmacol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Free Univ Berlin, Clin Benjamin Franklin, Inst Clin Pharmacol, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 armacol, D-12200 Berlin, Germany
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 2-3, volume: 79, anno: 2001,
pagine: 76 - 102
SICI:
0946-2716(200104)79:2-3<76:TRSNIF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITION; II-RECEPTOR SUBTYPES; LEFT-VENTRICULAR HYPERTROPHY; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA EXPRESSION; VASCULAR SMOOTH-MUSCLE; NEONATAL RAT-HEART; INDUCED CARDIOMYOCYTE HYPERTROPHY; STIMULATED ALDOSTERONE PRODUCTION; VASOACTIVE INTESTINAL PEPTIDE;
Keywords:
renin; angiotensin; transgenic rats; gene targeting;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
422
Recensione:
Indirizzi per estratti:
Indirizzo: Bader, J Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany D-13092 Berlin, Germany
Citazione:
J. Bader et al., "Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research", J MOL MED-J, 79(2-3), 2001, pp. 76-102

Abstract

Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost 50 additional years were: necessary to isolate the renin substrate angiotensinogen and to show its cleavage to angiotensin (Ang). Further studies were then needed to demonstrate that Ang I is converted via an angiotensin-converting enzyme to Ang II. The circulating renin-angiotensin system, with blood pressure regulatory and aldosterone stimulatory roles,sen ed well for decades. However more recent information on Ang II and itsaction in terms of cell proliferation, hypertrophy, and hyperplasia as well as immune-modulatory and even intracellular functions, have focused attention on local Ang II generation and effects. These investigations necessarily began in the kidney, but quickly moved to other organs including the brain, heart, adrenal gland, and vessel wall and formed the basis for the concept of independent tissue renin-angiotensin systems. Both renin and Ang II have even been implicated in intracellular activities. This review presentssome selected aspects of the historical development of this concept and summarizes discoveries relying primarily on animal models which demonstrate that Ang II is generated locally and acts in tissues as a local peptidergic system. Comprehensiveness in such an endeavor is not possible. We focus largely on Work from our own group, not because the work is necessarily worthyof such scrutiny but rather because of our own familiarity With the contents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:16:33