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Titolo:
Risk factor-gene interaction in carotid atherosclerosis: effect of gene polymorphisms of renin-angiotensin system
Autore:
Tabara, Y; Kohara, K; Nakura, J; Miki, T;
Indirizzi:
Ehime Univ, Sch Med, Dept Geriatr Med, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 5, volume: 46, anno: 2001,
pagine: 278 - 284
SICI:
1434-5161(2001)46:5<278:RFIICA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL-WALL THICKNESS; CONVERTING ENZYME GENES; LEFT-VENTRICULAR MASS; APOLIPOPROTEIN-E; BLOOD-PRESSURE; ESSENTIAL-HYPERTENSION; I/D POLYMORPHISM; DELETION POLYMORPHISM; MEDIA THICKNESS; HEART-DISEASE;
Keywords:
carotid atherosclerosis; ACE; angio-tensinogen; AT1 receptor; apoE; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kohara, K Ehime Univ, Sch Med, Dept Geriatr Med, Shigenobu, Ehime 7910295,Japan Ehime Univ Shigenobu Ehime Japan 7910295 , Ehime 7910295, Japan
Citazione:
Y. Tabara et al., "Risk factor-gene interaction in carotid atherosclerosis: effect of gene polymorphisms of renin-angiotensin system", J HUM GENET, 46(5), 2001, pp. 278-284

Abstract

The risk factor-gene interaction in carotid atherosclerosis was investigated in 205 community-dwelling healthy subjects aged 50 years or more in Japan. The intima-media thickness (IMT) of the common carotid artery was evaluated by ultrasonography with a 7.5-MHz probe. Gene polymorphisms were determined for each subject with angiotensin-converting enzyme (ACE) insertion/deletion (IID), angiotensinogen (AGT) M235T, angiotensin II type 1 receptor (AT1R) A1166C, and apolipoprotein E (apoE) genotypes. There was no genotype-specific difference in carotid IMT among any genes examined. Combinations of genotypes did not increase carotid IMT compared with subjects without these genotypes. In the total population, multiple regression analysis showed that age, systolic blood pressure (SBP), sex, and body mass index (BMI) were significantly associated with carotid IMT. However, the association between risk factors and IMT was genotype-specific. Age was significantly associated with IMT in ACE D carriers, but not in subjects with the ACE II genotype. Analysis of covariance adjusted with other risk factors showed that theage-dependent change in IR IT was significantly different between subjectswith the ACE II genotype and the ACE D carriers (F[1.196] = 4.97, P = 0.027). Similarly, the regression of IMT on SEP was significantly different between AGT TT and AGT MT + MM (F[1.196] = 7.20; P = 0.0079). The regression of IMT on BMI was also significantly different between apo E4 carriers and noncarriers (F[1.196] = 6.78; P = 0.0099). Furthermore, general linear modelanalysis with risk factors, genotype, and risk factor-genotype interactions revealed that the age*ACE genotype interaction, the SBP*AGT genotype interaction, and the BMI*apoE genotype interaction were significantly associated with IMT. These findings further support the role of risk factor-gene interaction in carotid atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:09:44