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Titolo:
Interchromosomal effect leading to an increase in aneuploidy in sperm nuclei in a man heterozygous for pericentric inversion (inv 9) and C-heterochromatin
Autore:
Amiel, A; Sardos-Albertini, F; Fejgin, MD; Sharony, R; Diukman, R; Bartoov, B;
Indirizzi:
Meir Hosp, Genet Inst, IL-44281 Kefar Sava, Israel Meir Hosp Kefar Sava Israel IL-44281 t Inst, IL-44281 Kefar Sava, Israel Lady Davies Carmel Med Ctr, Dept Obstet & Gynecol, Haifa, Israel Lady Davies Carmel Med Ctr Haifa Israel Obstet & Gynecol, Haifa, Israel Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel an Univ, Fac Life Sci, Ramat Gan, Israel
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 5, volume: 46, anno: 2001,
pagine: 245 - 250
SICI:
1434-5161(2001)46:5<245:IELTAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME COMPLEMENTS; REPRODUCTIVE FAILURE; SITU HYBRIDIZATION; SEGREGATION; DUPLICATION; FREQUENCY; MOSAICISM; COUPLES; 2-COLOR;
Keywords:
interchromosomal effect; inversion (9); FISH; aneuploidy; disomy; heterochromatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Amiel, A Meir Hosp, Genet Inst, IL-44281 Kefar Sava, Israel Meir Hosp Kefar Sava Israel IL-44281 L-44281 Kefar Sava, Israel
Citazione:
A. Amiel et al., "Interchromosomal effect leading to an increase in aneuploidy in sperm nuclei in a man heterozygous for pericentric inversion (inv 9) and C-heterochromatin", J HUM GENET, 46(5), 2001, pp. 245-250

Abstract

We describe a man with pericentric inversion 9 and constitutive heterochromatin, and a high disomy rate in his sperm cells (with all probes analyzed). The disomy rate was estimated with the following probes: 8, 9. 18, X, andY, and was significantly higher than that in control sperm cells, while chromosome 9 showed the highest disomy frequency. The probes of X and Y together showed the same disomy frequency as X and Y alone, which indicates the same non disjunction rate in the first meiotic division. We suggest that the interchromosomal effect found in this man differed from other findings insperm cells of men carrying an inversion in terms of the difference in thelength of the heterochromatin between the two chromosomes 9. Also, it is well known that the effect of inversion 9 with increased heterochromatin is highly variable and may even vary in members of the same family.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:48:45