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Titolo:
Prolonged survival of rat cardiac allograft with proinflammatory cytokine inhibitor
Autore:
Sano, I; Takahashi, T; Koji, T; Udono, H; Yui, K; Ayabe, H;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 ept Surg 1, Nagasaki 8528501, Japan Nagasaki Univ, Sch Med, Dept Histol & Cell Biol, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 Cell Biol, Nagasaki 8528501, Japan Nagasaki Univ, Sch Med, Dept Med Zool & Immunol, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 & Immunol, Nagasaki 8528501, Japan
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 5, volume: 20, anno: 2001,
pagine: 583 - 589
SICI:
1053-2498(200105)20:5<583:PSORCA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN T-CELLS; FACTOR-ALPHA; ENDOTHELIAL-CELLS; ANTI-TNF; EXPRESSION; INTERLEUKIN-1; REJECTION; FR167653; ENDOTOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Sano, I Nagasaki Univ, Sch Med, Dept Surg 1, 1-7-1 Sakamoto, Nagasaki 8528501, Japan Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528501 528501, Japan
Citazione:
I. Sano et al., "Prolonged survival of rat cardiac allograft with proinflammatory cytokine inhibitor", J HEART LUN, 20(5), 2001, pp. 583-589

Abstract

Background: Proinflammatory cytokines, such as tumor necrosis factor (TNF-alpha) and interleukin-1 (IL-1), play important roles in acute allograft rejection. FR167653 is an inhibitor of these cytokines that acts through inhibition of the mitogen-activated protein kinase p38 pathway. We examined theeffect of FR167653 on allograft rejection. Methods: We used Brown-Norway and Lewis rats as donors and recipients, respectively. We performed heterotopic cardiac transplantation. The control group consisted of untreated rats. In the experimental groups, recipients were intraperitoneally injected with FR167653 just after operation, followed by daily injection of the drug from Day 1 to 10. We divided 20 rats into 5 groups, which received varying doses of FR167653, ranging from 75 to 300 mg/kg/day. Results: In the control group, the mean graft survival was 6.8 +/- 0.3 days. FR167653 at 150 mg/kg/day significantly prolonged the survival period (up to 12.1 +/- 1.5 days, p = 0.002). Histologically, FR167653 markedly suppressed cellular infiltration on Day 5. post-transplantation. The serum levelof TNF-alpha in the control group was persistently elevated:from 9.3 +/- 3.9 pg/ml to 11.3 +/- 3.8 pg/ml, whereas FR167653 significantly suppressed the level to <1.4 +/- 1.4 pg/ml. Conclusions: FR167653 prolonged rat cardiac allograft survival by suppressing the action of proinflammatory cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:17:41