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Titolo:
Lymphocytic hypophysitis: Its expanding features
Autore:
Nakamura, Y; Okada, H; Wada, Y; Kajiyama, K; Koshiyama, H;
Indirizzi:
Hyogo Prefectural Amagasaki Hosp, Dept Internal Med, Div Endocrinol & Metab, Amagasaki, Hyogo 6600828, Japan Hyogo Prefectural Amagasaki Hosp Amagasaki Hyogo Japan 6600828 828, Japan Kansai Rosai Hosp, Dept Neurol, Kansai Rosai, Japan Kansai Rosai Hosp Kansai Rosai Japan , Dept Neurol, Kansai Rosai, Japan
Titolo Testata:
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
fascicolo: 4, volume: 24, anno: 2001,
pagine: 262 - 267
SICI:
0391-4097(200104)24:4<262:LHIEF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOLOSA-HUNT SYNDROME; DIABETES-INSIPIDUS; GRANULOMATOUS HYPOPHYSITIS; CAVERNOUS SINUS; HYPOPITUITARISM; INVOLVEMENT; INFUNDIBULONEUROHYPOPHYSITIS; DEFICIENCY; SELLA;
Keywords:
lymphocytic hypophysitis; hypopituitarism; ADH hyposecretion; diplopia; dura mater thickening; Hashimoto's thyroiditis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, Y Hyogo Prefectural Amagasaki Hosp, Dept Internal Med, Div Endocrinol & Metab, 1-1-1 Higashi Daimotsu Cho, Amagasaki, Hyogo 6600828, Japan Hyogo Prefectural Amagasaki Hosp 1-1-1 Higashi Daimotsu Cho Amagasaki HyogoJapan 6600828
Citazione:
Y. Nakamura et al., "Lymphocytic hypophysitis: Its expanding features", J ENDOC INV, 24(4), 2001, pp. 262-267

Abstract

Lymphocytic hypophysitis is classically defined as an inflammatory disorder confined to adenohypophysis However, it has recently been indicated that infundibuloneurohypophysitis underlies some subsets of central diabetes insipidus (DI). Therefore, lymphocytic hypophysitis can be considered a syndrome including disorders of both the anterior pituitary (lymphocytic adenohypophysitis) and the posterior pituitary (lymphocytic infundibuloneurohypophysitis). We describe a 77-yr-old woman with lymphocytic hypophysitis presenting with headache, diplopia, general malaise and appetite loss. Head magnetic resonance imaging (MRI) demonstrated pituitary swelling and dura mater thickening on the dorsum sella. Endocrinological investigations revealed both anterior and posterior pituitary dysfunction associated with primary hypothyroidism due to Hashimoto's thyroiditis. Headache and diplopia spontaneously disappeared, and anterior pituitary dysfunction, general malaise and appetite loss improved after taking 10 mg hydrocortisone daily, although ACTHhyposecretion persisted. Pituitary swelling was thereafter reduced but thedura mater thickening persisted. We suggest that this case may represent avariant of lymphocytic hypophysitis in which chronic inflammatory process involves both the anterior and the posterior pituitary gland, infundibulum,dura mater on the dorsum sella and cavernous sinus. Regarding expanding features of lymphocytic hypophysitis, it may be considered a syndrome including heterogeneous disorders, of which the pathogenesis remains to be elucidated. (C) 2001, Editrice Kurtis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:07:38