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Titolo:
Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma
Autore:
Kim, HK; Chung, YH; Song, BC; Yang, SH; Yoon, HK; Yu, E; Sung, KB; Lee, YS; Lee, SG; Suh, DJ;
Indirizzi:
Univ Ulsan, Asan Med Ctr, Coll Med, Dept Internal Med,Songpa Ku, Seoul 138040, South Korea Univ Ulsan Seoul South Korea 138040 Songpa Ku, Seoul 138040, South Korea Univ Ulsan, Asan Med Ctr, Coll Med, Dept Diagnost Radiol, Seoul 138040, South Korea Univ Ulsan Seoul South Korea 138040 st Radiol, Seoul 138040, South Korea Univ Ulsan, Asan Med Ctr, Coll Med, Dept Gen Surg, Seoul 138040, South Korea Univ Ulsan Seoul South Korea 138040 Gen Surg, Seoul 138040, South Korea Univ Ulsan, Asan Med Ctr, Coll Med, Dept Pathol, Seoul 138040, South KoreaUniv Ulsan Seoul South Korea 138040 pt Pathol, Seoul 138040, South Korea
Titolo Testata:
JOURNAL OF CLINICAL GASTROENTEROLOGY
fascicolo: 5, volume: 32, anno: 2001,
pagine: 423 - 427
SICI:
0192-0790(200105/06)32:5<423:IBDIAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; IODIZED OIL; VASCULAR PLEXUS; EMBOLIZATION; LIVER; CHEMOTHERAPY; STRICTURES; NECROSIS; THERAPY; BILOMA;
Keywords:
ischemic bile duct injury; transarterial chemoembolization; hepatocellular carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, YH Univ Ulsan, Asan Med Ctr, Coll Med, Dept Internal Med,Songpa Ku,388-1 Pungnapdong, Seoul 138040, South Korea Univ Ulsan 388-1 Pungnapdong Seoul South Korea 138040 uth Korea
Citazione:
H.K. Kim et al., "Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma", J CLIN GAST, 32(5), 2001, pp. 423-427

Abstract

Background: Bile duct injuries after transarterial chemoembolization (TACE) have been reported; however, the exact pathogenic mechanisms and clinicalimplications of the injuries remain to be clarified. Study: A total of 950consecutive patients with hepatocellular carcinoma (HCC) were studied. Among them, 807 were treated with TACE and the remaining 143 were treated withtransarterial chemoinfusion (TACI) of cisplatin. Results: None of 143 patients with HCC treated with TACI were found to have any radiographic evidence of biliary injury. In contrast, of the 807 patients treated with TACE, 17(2%) developed biliary complications. Of all complications, 12 (71%) were subcapsular bilomas; 3 (17%), focal strictures of the common hepatic duct or common bile duct; and 2 (12%), diffuse mild dilatation of the intrahepatic bile ducts, interestingly, 2 of the 12 bilomas were found in the lobe that was not embolized with gelatin sponge particles. The median numbers of TACE tended to be greater in the patients with focal stricture than in those with bilomas (6.0 vs. 2.5; p = 0.08). All 3 patients with focal strictures and 3 of the 12 patients with bilomas had associated serious bacterial infections at presentation. Conclusions: Bilomas seem to be caused by iodized oil rather than gelatin sponge particles; focal strictures of large bile ducts seem to be caused by gelatin sponge particles. We suggest that adjustments in the amounts of iodized oil or gelatin sponge particles and in the sites of embolization may reduce ischemic biliary injuries after TACE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 07:18:54