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Titolo:
Effect of parathyroid hormone (hPTH[1-84]) treatment on bone mass and strength in ovariectomized rats
Autore:
Akhter, MP; Kimmel, DB; Recker, RR;
Indirizzi:
Creighton Univ, Osteoporosis Res Ctr, Omaha, NE 68131 USA Creighton Univ Omaha NE USA 68131 teoporosis Res Ctr, Omaha, NE 68131 USA Merck Res Labs, W Point, PA USA Merck Res Labs W Point PA USAMerck Res Labs, W Point, PA USA
Titolo Testata:
JOURNAL OF CLINICAL DENSITOMETRY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 13 - 23
SICI:
1094-6950(200121)4:1<13:EOPH(T>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIRESORPTIVE AGENTS ESTROGEN; GROWTH-FACTOR-I; CORTICAL BONE; SEXUALLY MATURE; FEMORAL-NECK; BIOMECHANICAL COMPETENCE; MECHANICAL STRENGTH; COMBINATION THERAPY; CANCELLOUS BONE; ADULT-RATS;
Keywords:
parathyroid hormone; rats; bone strength; ovariectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Akhter, MP Creighton Univ, Osteoporosis Res Ctr, Suite 4820,601 N 30th St,Omaha, NE 68131 USA Creighton Univ Suite 4820,601 N 30th St Omaha NE USA 68131 USA
Citazione:
M.P. Akhter et al., "Effect of parathyroid hormone (hPTH[1-84]) treatment on bone mass and strength in ovariectomized rats", J CLIN DENS, 4(1), 2001, pp. 13-23

Abstract

Skeletal fragility in osteoporotic patients is a prominent underlying cause of low-trauma fractures of most bone sites in humans. Clinical research is now focused on developing treatment strategies, including anabolic agentssuch as parathyroid hormone (PTH), to recover osteoporosis related bone loss. Female Sprague-Dawley rats (4.5 mos old) were allowed to become osteopenic for 10 wk postovariectomy. Eight rats were killed at the time of ovariectomy (-10 wk) as a baseline control; sham and ovariectomized (OVX) groups were killed at wk 0. Eight rats per group (sham, OVX + vehicle, OVX + hPTH [5 d/wk], and OVX + hPTH [3 d/wk]) were killed after 4, 8, 14, and 20 wk oftreatment with 50 mug/kg of human parathyroid hormone (hPTH[1-84]). Bone mineral content and density were measured only in the vertebral body. Bone strength was evaluated in the vertebral body, femoral diaphysis, femoral neck, and distal femur. Significant, lasting osteopenia developed in the vertebral body of OVX rats by 10 wk postovariectomy. Bone mineral density of thevertebral body partially recovered by 8 wk and fully recovered to that seen in sham animals only by 20 wk posttreatment with either a 5 or 3 d/wk dosing schedule of PTH[1-84]. Therefore, hPTH[1-84] (50 mug/kg) given either 3or 5 d/wk fully restores vertebral and femoral bone strength in osteopenicOVX rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:36:52