Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Determination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection
Autore:
Llerena, A; Berecz, R; Norberto, MJ; de la Rubia, A;
Indirizzi:
Univ Extremadura, Fac Med, Dept Pharmacol & Psychiat, Unit Res & Clin Psychopharmacol, Badajoz 06071, Spain Univ Extremadura Badajoz Spain 06071 ychopharmacol, Badajoz 06071, Spain
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 755, anno: 2001,
pagine: 349 - 354
SICI:
1387-2273(20010505)755:1-2<349:DOCAIN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID-PHASE EXTRACTION; HUMAN PLASMA; MAJOR METABOLITES; NORCLOZAPINE; DISPOSITION; SERUM; DEBRISOQUINE; UPDATE;
Keywords:
clozapine; N-desmethyl clozapine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Llerena, A Univ Extremadura, Fac Med, Dept Pharmacol & Psychiat, Unit Res & Clin Psychopharmacol, Avda Elvas S-N, Badajoz 06071, Spain Univ Extremadura Avda Elvas S-N Badajoz Spain 06071 071, Spain
Citazione:
A. Llerena et al., "Determination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection", J CHROMAT B, 755(1-2), 2001, pp. 349-354

Abstract

A rapid high-performance liquid chromatographic method has been developed for the simultaneous determination of the atypical antipsychotic drug clozapine and its principal metabolite, N-desmethyl clozapine in human plasma. After liquid-liquid extraction the compounds were separated in a reversed-phase column and measured by ultraviolet absorption at 230 nm. For both compounds inter-day variations were <3.8%, and, based on a plasma sample volume of 2 ml, the limits of quantification were 25 ng/ml. Analytical interference from coadministered psychoactive drugs and their metabolites was also studied, and no interference was found from the most commonly used antidepressants and antipsychotic drugs. The assay is sufficiently sensitive and easy to use for the analysis of plasma samples in human clinical trials and therapeutic drug monitoring. (C) 2001 Elsevier Science B.V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:07:35