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Titolo:
Study on the electrochemical detection of the macrolide antibiotics clarithromycin and roxithromycin in reversed-phase high-performance liquid chromatography
Autore:
Pappa-Louisi, A; Papageorgiou, A; Zitrou, A; Sotiropoulos, S; Georgarakis, E; Zougrou, F;
Indirizzi:
Aristotelian Univ Salonika, Dept Chem, Phys Chem Lab, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece Aristotelian Univ Salonika, Dept Pharm, Sect Pharmaceut & Drug Control, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 755, anno: 2001,
pagine: 57 - 64
SICI:
1387-2273(20010505)755:1-2<57:SOTEDO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPEROMETRIC DETECTION; HUMAN-PLASMA; ERYTHROMYCIN; AZITHROMYCIN; ASSAY; SERUM; URINE;
Keywords:
clarithromycin; roxithromycin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Pappa-Louisi, A Aristotelian Univ Salonika, Dept Chem, Phys Chem Lab, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006eece
Citazione:
A. Pappa-Louisi et al., "Study on the electrochemical detection of the macrolide antibiotics clarithromycin and roxithromycin in reversed-phase high-performance liquid chromatography", J CHROMAT B, 755(1-2), 2001, pp. 57-64

Abstract

The optimal conditions of the amperometric detection of the macrolide antibiotics clarithromycin and roxithromycin were found by cyclic voltammetric studies and HPLC-electrochemical detection responses obtained in different temperatures (25.5-60 degreesC) and different but almost isoelutropic binary, ternary and quaternary mixtures of aqueous buffer (pH 7), methanol, acetonitrile and isopropanol. These conditions were also proved to be applicable for the quantitative detection of clarithromycin in human plasma using roxithromycin as an internal standard and vice verse. It was demonstrated that increased attention has to be paid to eluent composition and column temperature to ensure sensitive and reproducible electrochemical responses as well as regularly shaped peaks for both macrolides tested. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:40:22