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Titolo:
Rapid capillary electrophoretic method for the determination of clozapine and desmethylclozapine in human plasma
Autore:
Raggi, MA; Bugamelli, F; Mandrioli, R; Sabbioni, C; Volterra, V; Fanali, S;
Indirizzi:
Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 Sci Farmaceut, I-40126 Bologna, Italy Univ Bologna, Clin Psichiatr, I-40123 Bologna, Italy Univ Bologna Bologna Italy I-40123 lin Psichiatr, I-40123 Bologna, Italy Area Ric Padova, Ist Cromatog, CNR, I-00016 Rome, Italy Area Ric Padova Rome Italy I-00016 st Cromatog, CNR, I-00016 Rome, Italy
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1-2, volume: 916, anno: 2001,
pagine: 289 - 296
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; SCHIZOPHRENIC-PATIENTS; ULTRAVIOLET DETECTION; MAJOR METABOLITES; HUMAN-SERUM; AMPEROMETRIC DETECTION; ENANTIOMERS; SEPARATION; SAMPLES;
Keywords:
clozapine; desmethylclozapine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Raggi, MA Univ Bologna, Dipartimento Sci Farmaceut, Via Belmeloro 6, I-40126 Bologna, Italy Univ Bologna Via Belmeloro 6 Bologna Italy I-40126 logna, Italy
Citazione:
M.A. Raggi et al., "Rapid capillary electrophoretic method for the determination of clozapine and desmethylclozapine in human plasma", J CHROMAT A, 916(1-2), 2001, pp. 289-296

Abstract

A rapid and sensitive high-performance capillary electrophoretic method for the determination of clozapine and its main metabolite desmethylclozapinein human plasma was developed. The separation of the two analytes was carried out in an untreated fused-silica capillary [33 cm (8.5 cm effective length) X 50 mum ID.] filled with a background electrolyte at pH 2.5 containing P-cyclodextrin. Baseline separation of clozapine and desmethylclozapine was recorded in less than 3 min. An accurate sample pretreatment by means ofsolid-phase extraction and subsequent concentration allows for reliable quantitation of clozapine in the plasma of schizophrenic patients under treatment with the drug. The method showed good precision (mean RSD = 4.0%) as well as satisfactory extraction yields (similar to 88%) and a good sensitivity (limit of quantitation= 0.075 mug ml(-1), limit of detection = 0.025 mugml(-1)). (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:23:59