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Titolo:
Sp1 phosphorylation regulates apoptosis via extracellular FsasL-Fas engagement
Autore:
Kavurma, MM; Santiago, FS; Bonfoco, E; Khachigian, LM;
Indirizzi:
Univ New S Wales, Ctr Thrombosis & Vasc Res, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 s, Sydney, NSW 2052, Australia Scripps Res Inst, La Jolla, CA 92037 USA Scripps Res Inst La Jolla CA USA92037 s Res Inst, La Jolla, CA 92037 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 7, volume: 276, anno: 2001,
pagine: 4964 - 4971
SICI:
0021-9258(20010216)276:7<4964:SPRAVE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; PROTEIN-KINASE-C; HUMAN ATHEROSCLEROTIC LESIONS; T-CELLS; TRANSCRIPTIONAL REGULATION; GLUCOSE-TRANSPORT; LIGAND EXPRESSION; OKADAIC ACID; HIV-1 TAT; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Khachigian, LM Univ New S Wales, Ctr Thrombosis & Vasc Res, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 2052, Australia
Citazione:
M.M. Kavurma et al., "Sp1 phosphorylation regulates apoptosis via extracellular FsasL-Fas engagement", J BIOL CHEM, 276(7), 2001, pp. 4964-4971

Abstract

Apoptosis of smooth muscle cells (SMC) in atherosclerotic vessels can destabilize the atheromatus plaque and result in rupture, thrombosis, and sudden death. In efforts to understand the molecular processes regulating apoptosis in this cell type, we have defined a novel mechanism involving the ubiquitously expressed transcription factor Sp1. Subtypes of SMC expressing abundant levels of Spl produce the death agonist, Fas ligand (FasL) and undergo greater spontaneous apoptosis, Sp1 activates the FasL promoter via a distinct nucleotide recognition element whose integrity is crucial for inducible expression. Inducible FasL promoter activation is also inhibited by a dominant-negative form of Sp1, Increased SMC apoptosis is preceded by Sp1 phosphorylation, increased FasL transcription, and the autocrine/ paracrine engagement of FasL with its cell-surface receptor, Fas, Inducible FasL transcription and apoptosis are blocked by dominant-negative protein kinase C-zeta, whose wild-type counterpart phosphorylates Sp1. Thus, Sp1 phosphorylationis a proapoptotic transcriptional event in vascular SMC and, given the wide distribution of this housekeeping transcription factor, may be a common regulatory theme in apoptotic signal transduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:49:41