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Titolo:
Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone
Autore:
Benard, O; Naor, Z; Seger, R;
Indirizzi:
Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 Biol, IL-76100 Rehovot, Israel Tel Aviv Univ, Dept Biochem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 iochem, IL-69978 Tel Aviv, Israel
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 7, volume: 276, anno: 2001,
pagine: 4554 - 4563
SICI:
0021-9258(20010216)276:7<4554:RODSAR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
G-BETA-GAMMA; COUPLED RECEPTOR INTERNALIZATION; SIGNAL-REGULATED KINASE; ALPHA-T3-1 CELL-LINE; MAP KINASE; TYROSINE-KINASE; DIFFERENTIAL ACTIVATION; DEPENDENT ACTIVATION; GROWTH-FACTOR; MUSCLE CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Seger, R Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
O. Benard et al., "Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone", J BIOL CHEM, 276(7), 2001, pp. 4554-4563

Abstract

G-protein-coupled receptors are a large group of integral membranal receptors, which in response to ligand binding initiate diverse downstream signaling. Here we studied the gonadotropin-releasing hormone (GnRH) receptor, which uses Gq for its downstream signaling. We show that extracellular signal-regulated kinase (ERK) activation is fully dependent on protein kinase C (PKC), but only partially dependent on Src, dynamin, and Ras. Receptor tyrosine kinases, FAK, G beta gamma, and beta -arrestin, which were implicated in some G-protein-coupled receptor signaling to MAPK cascades, do not play arole in the GnRH to ERK pathway. Our results suggest that the activation of ERK by GnRH involves two distinct signaling pathways, which converge at the level of Raf-1. The main pathway involves a direct activation of Raf-1 by PKC, and this step is partially dependent on a second pathway consisting of Ras activation, which occurs in a dynamin-dependent manner, downstream of Src.

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Documento generato il 01/04/20 alle ore 02:05:35