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Titolo:
Regulation of phosphatidylserine transbilayer redistribution by store-operated Ca2+ entry - Role of actin cytoskeleton
Autore:
Kunzelmann-Marche, C; Freyssinet, JM; Martinez, MC;
Indirizzi:
Univ Strasbourg 1, Fac Med, Inst Hematol & Immunol, F-67085 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67085 , F-67085 Strasbourg, France Hop Bicetre, INSERM, U143, F-94275 Le Kremlin Bicetre, France Hop BicetreLe Kremlin Bicetre France F-94275 Le Kremlin Bicetre, France
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 7, volume: 276, anno: 2001,
pagine: 5134 - 5139
SICI:
0021-9258(20010216)276:7<5134:ROPTRB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPACITATIVE CALCIUM-ENTRY; PLATELET PLASMA-MEMBRANE; MICROPARTICLE FORMATION; PHOSPHOLIPID ASYMMETRY; SCOTT SYNDROME; AMINOPHOSPHOLIPID EXPOSURE; PROCOAGULANT ACTIVITY; MOLECULAR-CLONING; BLOOD-PLATELETS; LIPID ASYMMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez, MC Univ Strasbourg 1, Fac Med, Inst Hematol & Immunol, 4 Rue Kirschleger, F-67085 Strasbourg, France Univ Strasbourg 1 4 Rue Kirschleger Strasbourg France F-67085
Citazione:
C. Kunzelmann-Marche et al., "Regulation of phosphatidylserine transbilayer redistribution by store-operated Ca2+ entry - Role of actin cytoskeleton", J BIOL CHEM, 276(7), 2001, pp. 5134-5139

Abstract

The phosphatidylserine transmembrane redistribution at the cell surface isone of the early characteristics of cells undergoing apoptosis and also occurs in cells fulfilling a more specialized function, such as the phosphatidylserine-dependent procoagulant response of platelets after appropriate activation. Although an increase in cytoplasmic Ca2+ is essential to trigger the remodeling of the plasma membrane, little is known about intracellular signals leading to phosphatidylserine externalization, Here, the role of store-operated Ca2+ entry on phosphatidylserine exposure was investigated in human erythroleukemia HEL cells, a pluripotent lineage with megakaryoblastic properties. Ca2+ entry inhibitors (SKF-96365, LaCl3, and miconazole) inhibited store-operated Ca2+ entry in A23187- or thapsigargin-stimulated cellsand reduced the degree of phosphatidylserine externalization concomitantly, providing evidence for a close link between the two processes. In cells pretreated with cytochalasin D, an agent that disrupts the microfilament network of the cytoskeleton, store-operated Ca2+ entry and phosphatidylserine externalization at the cell surface were inhibited, In a context where mostof the key actors remain to be identified, these results provide evidence for the implication of both store-operated Ca2+ entry and cytoskeleton architectural organization in the regulation of phosphatidylserine transbilayermigration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:26:19