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Titolo:
Effects of recombinant human macrophage colony-stimulating factor on atherosclerotic lesions established in the aorta of high cholesterol-fed rabbits
Autore:
Irie, H; Koshiba, H; Koyama, M; Asakura, E; Shibata, H; Kimura, K; Naito, K; Yamauchi, T; Yada, K; Hanamura, T; Hanada, S; Abe, S; Nakamura, N;
Indirizzi:
Welfide Corp, Div Pharmaceut Res, Osaka 5731153, Japan Welfide Corp Osaka Japan 5731153 iv Pharmaceut Res, Osaka 5731153, Japan
Titolo Testata:
JOURNAL OF BIOCHEMISTRY
fascicolo: 5, volume: 129, anno: 2001,
pagine: 717 - 724
SICI:
0021-924X(200105)129:5<717:EORHMC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR M-CSF; HERITABLE HYPERLIPIDEMIC RABBITS; MONOCYTE-DERIVED MACROPHAGES; PLASMA-CHOLESTEROL; LOWERING ACTIVITY; FACTOR GENE; IN-VITRO; MICE; METABOLISM; CELLS;
Keywords:
atherosclerosis; cholesterol; HDL; M-CSF; reverse cholesterol transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, N 2-6-9 Hirano Cho,Chuo Ku, Osaka 5410046, Japan 2-6-9 Hirano Cho,Chuo Ku Osaka Japan 5410046 5410046, Japan
Citazione:
H. Irie et al., "Effects of recombinant human macrophage colony-stimulating factor on atherosclerotic lesions established in the aorta of high cholesterol-fed rabbits", J BIOCHEM, 129(5), 2001, pp. 717-724

Abstract

Anti-atherosclerotic effects of human macrophage colony-stimulating factorwere investigated using rabbits fed a high cholesterol diet. Rabbits fed adiet containing 2% cholesterol for 59 days developed hyperlipidemia and atheromatous aortic plaques. They were then administered 80 mug/kg/day of either macrophage colony-stimulating factor or human serum albumin, as a control, for the next 12 weeks. Compared with the control group, rabbits treatedwith macrophage colony-stimulating factor had significantly fewer plaques on the inner surface of the thoracic and abdominal aortae, and half the sectional area of thickened intima in the aortic arch, as well as in the thoracic and abdominal aortae. Macrophage colony-stimulating factor also decreased the cholesterol content of the atherosclerotic lesions. Serobiochemical analyses revealed that macrophage colony-stimulating factor increased the levels of high density lipoprotein-cholesterol significantly, without influencing other lipid parameters such as the level of low density lipoproteins. The effects of macrophage colony-stimulating factor were evident until thefourth week of drug injection, at which time anti-human macrophage colony-stimulating factor antibodies were clearly induced in the serum. These results indicate that exogenously administered macrophage colony-stimulating factor suppresses atherosclerotic lesions induced by a high cholesterol diet by activating lipid metabolism in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:05:20