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Titolo:
Effects of deoxycholic acid and its epimers on lipid peroxidation in isolated rat hepatocytes
Autore:
Hino, A; Morita, M; Une, M; Fujimura, K; Kuramoto, T;
Indirizzi:
Hiroshima Univ, Sch Med, Inst Pharmaceut Sci, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan
Titolo Testata:
JOURNAL OF BIOCHEMISTRY
fascicolo: 5, volume: 129, anno: 2001,
pagine: 683 - 689
SICI:
0021-924X(200105)129:5<683:EODAAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; BILE-ACIDS; LIVER-MITOCHONDRIA; FREE-RADICALS; VITAMIN-E; TAUROCHENODEOXYCHOLATE CONTENT; OXIDOREDUCTASE COMPLEX; BILIARY OBSTRUCTION; SUPEROXIDE ANION; HEPATIC-INJURY;
Keywords:
bile acid; hepatocyte; hepatotoxicity; hydrophilicity; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Kuramoto, T Hiroshima Univ, Sch Med, Inst Pharmaceut Sci, Minami Ku, Kasumi 1-2-3, Hiroshima 7348551, Japan Hiroshima Univ Kasumi 1-2-3 Hiroshima Japan 7348551 51, Japan
Citazione:
A. Hino et al., "Effects of deoxycholic acid and its epimers on lipid peroxidation in isolated rat hepatocytes", J BIOCHEM, 129(5), 2001, pp. 683-689

Abstract

We studied the effects of deoxycholic acid and its three epimers with beta-hydroxyl groups (3 alpha ,12 beta-, 3 beta ,12 alpha-, and 3 beta ,12 beta -dihydroxy-5 beta -cholan-24-oic acids), which were hydrophilic and less cytotoxic, on lipid peroxidation to elucidate the relationship between structural features of bile acids and their effect on lipid peroxidation. Taurodeoxycholate markedly increased the production of thiobarbituric acid-reactive substances, end products of lipid peroxidation, in isolated rat hepatocytes, whereas epimers of taurodeoxycholate did not. Deoxycholic acid inhibited mitochondrial NADH dehydrogenase and NADH:ferricytochrome c oxidoreductase activities, leading to free radical generation, whereas epimers of deoxycholic acid had no effect on mitochondrial enzymes. These findings suggested that hydrophobic bile acids cause lipid peroxidation by impairment of mitochondrial function, leading to the generation of free radicals; and epimerization of alpha -hydroxyl groups in the steroid nucleus to beta -hydroxylgroups results in a decrease of the toxic effects of deoxycholic acid on lipid peroxidation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:33:15