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Titolo:
National surveillance of HIV-1 subtypes for England and Wales - Design, methods, and initial findings
Autore:
Parry, JV; Murphy, G; Barlow, KL; Lewis, K; Rogers, PA; Belda, FJ; Nicoll, A; McGarrigle, C; Cliffe, S; Mortimer, PP; Clewley, JP;
Indirizzi:
Cent Publ Hlth Lab, SBVL, Sexually Transmitted & Blood Borne Virus Lab, London NW9 5HT, England Cent Publ Hlth Lab London England NW9 5HT s Lab, London NW9 5HT, England Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Stat Unit, London NW9 5EQ, England Publ Hlth Lab Serv London England NW9 5EQ Unit, London NW9 5EQ, England Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, HIV & STD Div, London NW9 5EQ, England Publ Hlth Lab Serv London England NW9 5EQ D Div, London NW9 5EQ, England
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 26, anno: 2001,
pagine: 381 - 388
SICI:
1525-4135(20010401)26:4<381:NSOHSF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; HETERODUPLEX MOBILITY ASSAY; GENETIC DIVERSITY; B STRAINS; V3 LOOP; SEQUENCE; THAILAND; PLASMA; RNA; QUANTIFICATION;
Keywords:
heterosexual transmission; HIV-1 subtypes; molecular epidemiology; surveillance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Clewley, JP Cent Publ Hlth Lab, SBVL, Sexually Transmitted & Blood Borne Virus Lab, 61Colindale Ave, London NW9 5HT, England Cent Publ Hlth Lab 61 Colindale Ave London England NW9 5HT nd
Citazione:
J.V. Parry et al., "National surveillance of HIV-1 subtypes for England and Wales - Design, methods, and initial findings", J ACQ IMM D, 26(4), 2001, pp. 381-388

Abstract

The HIV-1 infections detected in an ongoing national unlinked anonymous HIV surveillance program were subtyped and analyzed according to demographic and risk characteristics. Of the 893 anti-HIV-l-positive specimens allocated to an exposure group, 70% could be subtyped. Almost 25% of infections subtyped were non-B, mostly subtypes A, C, and D. Non-B infections were rare in homosexual and bisexual men and in drug injectors. Forty percent of infections in heterosexual men attending genitourinary medicine clinics were non-B subtypes; of these, 25% were subtype A infections and 59% were subtype Cinfections. For female clinic attendees, 61% were non-B subtype infections, of which 48% were subtype A infections and 42% were subtype C infections. Of the clinic attendees born in the United Kingdom and Europe, 14% of the men and 35% of the women were infected with non-B subtypes. In contrast, 78% of infections in antenatal patients were non-B subtypes, of which 61% were subtype A and 29% were subtype C. Extrapolation to the estimated 29,700 prevalent adult infections in the United Kingdom indicates that approximately 8,100 (27%) such infections are non-B subtypes and that these are found almost entirely in heterosexuals. The findings suggest spread of infection of non-B subtypes to heterosexuals born in the United Kingdom from individuals infected in regions of high prevalence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:22:49